| Rosacea
Zilxi vs Rhofade
Side-by-side clinical, coverage, and cost comparison for rosacea.Deep comparison between: Zilxi vs Rhofade with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsRhofade has a higher rate of injection site reactions vs Zilxi based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Rhofade but not Zilxi, including UnitedHealthcare
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Category
Zilxi
Rhofade
At A Glance
Topical
Daily
Tetracycline derivative
Topical
Daily
Alpha-1A adrenoceptor agonist
Indications
- Rosacea
- Rosacea
Dosing
Rosacea Apply a cherry-sized amount of foam to the entire face once daily at least 1 hour before bedtime; do not bathe, shower, or swim for at least 1 hour after application.
Rosacea Apply a pea-sized amount once daily in a thin layer to cover the entire face (forehead, nose, each cheek, and chin), avoiding the eyes and lips; wash hands immediately after applying.
Contraindications
- Hypersensitivity to any tetracycline or any other ingredient in ZILXI
—
Adverse Reactions
Most common (>=1%) Diarrhea
Most common (>=1%) application site dermatitis, worsening inflammatory lesions of rosacea, application site pruritus, application site erythema, application site pain
Pharmacology
Minocycline is a semi-synthetic derivative of tetracycline; its mechanism of action for the treatment of inflammatory lesions of rosacea is unknown.
Oxymetazoline is an alpha 1A adrenoceptor agonist that acts as a vasoconstrictor when applied topically to the face.
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Most Common Insurance
Anthem BCBS
Zilxi
- Covered on 5 commercial plans
- PA (4/12) · Step Therapy (4/12) · Qty limit (9/12)
Rhofade
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (6/12) · Qty limit (9/12)
UnitedHealthcare
Zilxi
- Covered on 4 commercial plans
- PA (3/8) · Step Therapy (3/8) · Qty limit (3/8)
Rhofade
- Covered on 4 commercial plans
- PA (5/8) · Step Therapy (0/8) · Qty limit (1/8)
Humana
Zilxi
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (2/3) · Qty limit (2/3)
Rhofade
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (2/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Zilxi.
No savings programs available for Rhofade.
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RhofadeView full Rhofade profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.