| Thyroid carcinoma
Gavreto vs Retevmo
Side-by-side clinical, coverage, and cost comparison for thyroid carcinoma.Deep comparison between: Gavreto vs Retevmo with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsRetevmo has a higher rate of injection site reactions vs Gavreto based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Retevmo but not Gavreto, including UnitedHealthcare
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Category
Gavreto
Retevmo
At A Glance
Oral
Once daily
RET kinase inhibitor
Oral
Twice daily
RET kinase inhibitor
Indications
- Metastatic Lung Non-Small Cell Carcinoma
- Thyroid carcinoma
- Non-Small Cell Lung Carcinoma
- Medullary carcinoma of thyroid
- Thyroid carcinoma
Dosing
Metastatic Lung Non-Small Cell Carcinoma, Thyroid carcinoma 400 mg orally once daily on an empty stomach (no food intake for at least 2 hours before and at least 1 hour after); continue until disease progression or unacceptable toxicity.
Non-Small Cell Lung Carcinoma, Medullary carcinoma of thyroid, Thyroid carcinoma Adults and adolescents >= 12 years: 120 mg orally twice daily (< 50 kg) or 160 mg orally twice daily (>= 50 kg); pediatric patients 2 to < 12 years: 40 mg three times daily to 160 mg twice daily orally based on body surface area; administered until disease progression or unacceptable toxicity.
Contraindications
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Adverse Reactions
Most common (>=25%) Musculoskeletal pain, constipation, hypertension, diarrhea, fatigue, edema, pyrexia, cough
Serious ILD/Pneumonitis, hypertension, hepatotoxicity, hemorrhagic events, tumor lysis syndrome, impaired wound healing, embryo-fetal toxicity
Most common (>=25%) edema, diarrhea, fatigue, dry mouth, hypertension, abdominal pain, constipation, rash, nausea, headache
Serious hepatotoxicity, interstitial lung disease/pneumonitis, hypertension, QT interval prolongation, hemorrhagic events, hypersensitivity, tumor lysis syndrome, impaired wound healing, hypothyroidism, slipped capital femoral epiphysis in adolescents
Postmarketing Stevens-Johnson Syndrome
Pharmacology
Pralsetinib is a kinase inhibitor of wild-type RET and oncogenic RET fusions and mutations (IC50s <0.5 nM), blocking downstream signaling pathways that drive uncontrolled tumor cell proliferation in RET fusion-positive NSCLC and thyroid cancer.
Selpercatinib is a kinase inhibitor that selectively inhibits wild-type RET and multiple mutated RET isoforms (including gene fusions and activating point mutations) as well as VEGFR1 and VEGFR3, and at clinically achievable concentrations also inhibits FGFR1, 2, and 3, blocking constitutive RET signaling that acts as an oncogenic driver promoting tumor cell proliferation.
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Most Common Insurance
Anthem BCBS
Gavreto
- Covered on 5 commercial plans
- PA (12/12) · Step Therapy (0/12) · Qty limit (11/12)
No coverage data available for Retevmo.
UnitedHealthcare
Gavreto
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (6/8)
Retevmo
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (6/8)
Humana
Gavreto
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Retevmo
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAssistance Fund: Non-Small Cell Lung Cancer (NSCLC)
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
No savings programs available for Retevmo.
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GavretoView full Gavreto profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.