| Thyroid carcinoma
Synthroid vs Retevmo
Side-by-side clinical, coverage, and cost comparison for thyroid carcinoma.Deep comparison between: Synthroid vs Retevmo with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsRetevmo has a higher rate of injection site reactions vs Synthroid based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Retevmo but not Synthroid, including UnitedHealthcare
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Category
Synthroid
Retevmo
At A Glance
Oral
Daily
Synthetic thyroid hormone (T4)
Oral
Twice daily
RET kinase inhibitor
Indications
- Hypothyroidism
- Thyroid carcinoma
- Non-Small Cell Lung Carcinoma
- Medullary carcinoma of thyroid
- Thyroid carcinoma
Dosing
Hypothyroidism Once daily oral dose on an empty stomach one-half to one hour before breakfast; full replacement starting dose is 1.6 mcg/kg/day in adults (lower starting dose for patients at cardiac risk or geriatric patients); titrate by 12.5 to 25 mcg increments every 4 to 6 weeks based on serum TSH or free-T4; pediatric dosing starts at 10 to 15 mcg/kg/day in neonates and decreases with age.
Thyroid carcinoma Once daily oral dose; dosage is based on the target level of TSH suppression for the stage and clinical status of well-differentiated thyroid cancer.
Non-Small Cell Lung Carcinoma, Medullary carcinoma of thyroid, Thyroid carcinoma Adults and adolescents >= 12 years: 120 mg orally twice daily (< 50 kg) or 160 mg orally twice daily (>= 50 kg); pediatric patients 2 to < 12 years: 40 mg three times daily to 160 mg twice daily orally based on body surface area; administered until disease progression or unacceptable toxicity.
Contraindications
- Uncorrected adrenal insufficiency
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Adverse Reactions
Most common Fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating, headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia, tremors, muscle weakness, muscle spasm, palpitations, tachycardia, arrhythmias, increased pulse and blood pressure, dyspnea, diarrhea, vomiting, abdominal cramps, elevated liver function tests, hair loss, flushing, rash, decreased bone mineral density, menstrual irregularities, impaired fertility.
Serious Heart failure, angina, myocardial infarction, cardiac arrest, seizures (rare); in pediatric patients: pseudotumor cerebri, slipped capital femoral epiphysis, craniosynostosis in infants, and premature epiphyseal closure.
Postmarketing Hypersensitivity reactions to inactive ingredients including urticaria, pruritus, skin rash, flushing, angioedema, gastrointestinal symptoms, fever, arthralgia, serum sickness, and wheezing.
Most common (>=25%) edema, diarrhea, fatigue, dry mouth, hypertension, abdominal pain, constipation, rash, nausea, headache
Serious hepatotoxicity, interstitial lung disease/pneumonitis, hypertension, QT interval prolongation, hemorrhagic events, hypersensitivity, tumor lysis syndrome, impaired wound healing, hypothyroidism, slipped capital femoral epiphysis in adolescents
Postmarketing Stevens-Johnson Syndrome
Pharmacology
Synthetic T4 (levothyroxine) exerts the same physiologic effect as endogenous thyroxine by binding thyroid receptor proteins in the cell nucleus to activate DNA transcription and protein synthesis; approximately 80% of circulating T3, the predominantly active form, is derived from peripheral deiodination of T4.
Selpercatinib is a kinase inhibitor that selectively inhibits wild-type RET and multiple mutated RET isoforms (including gene fusions and activating point mutations) as well as VEGFR1 and VEGFR3, and at clinically achievable concentrations also inhibits FGFR1, 2, and 3, blocking constitutive RET signaling that acts as an oncogenic driver promoting tumor cell proliferation.
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Most Common Insurance
Anthem BCBS
Synthroid
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (0/12)
No coverage data available for Retevmo.
UnitedHealthcare
Synthroid
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Retevmo
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (6/8)
Humana
Synthroid
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Retevmo
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Synthroid.
No savings programs available for Retevmo.
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SynthroidView full Synthroid profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.