| Thyroid carcinoma
Synthroid vs Tirosint SOL
Side-by-side clinical, coverage, and cost comparison for thyroid carcinoma.Deep comparison between: Synthroid vs Tirosint with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTirosint has a higher rate of injection site reactions vs Synthroid based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Tirosint but not Synthroid, including UnitedHealthcare
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Category
Synthroid
Tirosint
At A Glance
Oral
Daily
Synthetic thyroid hormone (T4)
Oral
Daily
Thyroid hormone (synthetic T4)
Indications
- Hypothyroidism
- Thyroid carcinoma
- Hypothyroidism
- Thyroid carcinoma
Dosing
Hypothyroidism Once daily oral dose on an empty stomach one-half to one hour before breakfast; full replacement starting dose is 1.6 mcg/kg/day in adults (lower starting dose for patients at cardiac risk or geriatric patients); titrate by 12.5 to 25 mcg increments every 4 to 6 weeks based on serum TSH or free-T4; pediatric dosing starts at 10 to 15 mcg/kg/day in neonates and decreases with age.
Thyroid carcinoma Once daily oral dose; dosage is based on the target level of TSH suppression for the stage and clinical status of well-differentiated thyroid cancer.
Hypothyroidism Once daily oral dose on empty stomach, 15 minutes before breakfast; adults start at 1.6 mcg/kg/day (lower in cardiac or geriatric patients), titrate by 12.5-25 mcg every 4-6 weeks; pediatric dosing weight-based by age (1.6-15 mcg/kg/day), titrated every 2 weeks; pregnant patients may require increased dose monitored every 4 weeks.
Thyroid carcinoma Once daily oral dose; dosage based on target level of TSH suppression for the stage and clinical status of well-differentiated thyroid cancer.
Contraindications
- Uncorrected adrenal insufficiency
- Hypersensitivity to glycerol (inactive ingredient in TIROSINT-SOL)
- Uncorrected adrenal insufficiency
Adverse Reactions
Most common Fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating, headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia, tremors, muscle weakness, muscle spasm, palpitations, tachycardia, arrhythmias, increased pulse and blood pressure, dyspnea, diarrhea, vomiting, abdominal cramps, elevated liver function tests, hair loss, flushing, rash, decreased bone mineral density, menstrual irregularities, impaired fertility.
Serious Heart failure, angina, myocardial infarction, cardiac arrest, seizures (rare); in pediatric patients: pseudotumor cerebri, slipped capital femoral epiphysis, craniosynostosis in infants, and premature epiphyseal closure.
Postmarketing Hypersensitivity reactions to inactive ingredients including urticaria, pruritus, skin rash, flushing, angioedema, gastrointestinal symptoms, fever, arthralgia, serum sickness, and wheezing.
Most common Fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating, headache, hyperactivity, nervousness, anxiety, irritability, insomnia, tremors, muscle weakness, palpitations, tachycardia, diarrhea, vomiting, abdominal cramps, hair loss, flushing, rash, decreased bone mineral density, menstrual irregularities, impaired fertility
Serious Arrhythmias, increased blood pressure, heart failure, angina, myocardial infarction, cardiac arrest, seizures (rare); pseudotumor cerebri and slipped capital femoral epiphysis in pediatric patients
Hypersensitivity Urticaria, pruritus, skin rash, flushing, angioedema, abdominal pain, nausea, vomiting, diarrhea, fever, arthralgia, serum sickness, wheezing
Pharmacology
Synthetic T4 (levothyroxine) exerts the same physiologic effect as endogenous thyroxine by binding thyroid receptor proteins in the cell nucleus to activate DNA transcription and protein synthesis; approximately 80% of circulating T3, the predominantly active form, is derived from peripheral deiodination of T4.
Synthetic T4 hormone (levothyroxine sodium) that exerts physiologic effects through control of DNA transcription and protein synthesis by binding thyroid receptor proteins attached to DNA in cell nuclei; the predominant active form T3 is derived approximately 80% from peripheral deiodination of T4, and oral levothyroxine maintains normal T4 levels when endogenous production is deficient.
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Most Common Insurance
Anthem BCBS
Synthroid
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (0/12)
Tirosint
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Synthroid
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Tirosint
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Synthroid
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Tirosint
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Synthroid.
No savings programs available for Tirosint.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.