| Urinary tract infection
Avycaz vs Doryx MPC
Side-by-side clinical, coverage, and cost comparison for urinary tract infection.Deep comparison between: Avycaz vs Doryx Mpc with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsDoryx Mpc has a higher rate of injection site reactions vs Avycaz based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Doryx Mpc but not Avycaz, including UnitedHealthcare
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Category
Avycaz
Doryx Mpc
At A Glance
IV infusion
Every 8 hours
Cephalosporin/beta-lactamase inhibitor
Oral
Once or twice daily
Tetracycline antibiotic
Indications
- Urinary Tract Infection
- Pneumonia, Bacterial
- Rocky Mountain Spotted Fever
- TYPHUS
- Q Fever
- Rickettsialpox
- non-gonococcal urethritis (NGU)
- Lymphogranuloma Venereum
- Granuloma Inguinale
- Gonorrhea
- Chancroid
- Psittacosis
- Respiratory Tract Infections
- Upper Respiratory Infections
- Relapsing Fever
- Plague
- Tularemia
- Cholera
- Brucellosis
- Bartonella Infections
- Trachoma
- Inclusion conjunctivitis
- Anthrax disease
- Syphilis
- Yaws
- Listeriosis
- Necrotizing Ulcerative Gingivitis
- Actinomycosis
- Amebiasis
- Acne Vulgaris
- Malaria
- Urethritis
- Uterine Cervicitis
- Proctitis
- Urinary tract infection
Dosing
Complicated Intra-abdominal Infections, Urinary Tract Infection, Pneumonia, Bacterial 2.5 grams (ceftazidime 2 grams and avibactam 0.5 grams) IV every 8 hours infused over 2 hours in adults with CrCl > 50 mL/min; cIAI requires concurrent metronidazole; dosage adjustment required for CrCl <=50 mL/min; duration 5-14 days (cIAI) or 7-14 days (cUTI, HABP/VABP).
Rocky Mountain Spotted Fever, TYPHUS, Q Fever, Rickettsialpox, Relapsing Fever, Plague, Tularemia, Cholera, Brucellosis, Bartonella Infections, Psittacosis, Respiratory Tract Infections, Upper Respiratory Infections, Trachoma, Inclusion conjunctivitis, Yaws, Listeriosis, Necrotizing Ulcerative Gingivitis, Actinomycosis, Amebiasis, Acne Vulgaris, Urinary tract infection Adults: 240 mg on day 1 (120 mg every 12 hours), then 120 mg daily maintenance; for severe infections (e.g., chronic urinary tract infections), 120 mg every 12 hours. Pediatric <45 kg (>8 years, less severe disease): 5.3 mg/kg divided in 2 doses on day 1, then 2.6 mg/kg daily; severe or life-threatening infections: 2.6 mg/kg every 12 hours. Pediatric >=45 kg: adult dose.
non-gonococcal urethritis (NGU), Urethritis, Uterine Cervicitis, Proctitis 120 mg orally twice daily for 7 days.
Gonorrhea 120 mg orally twice daily for 7 days; alternate single-visit dose: 360 mg followed in 1 hour by a second 360 mg dose.
Syphilis (early, penicillin allergy) 120 mg orally twice daily for 2 weeks.
Syphilis (>1 year duration, penicillin allergy) 120 mg orally twice daily for 4 weeks.
Anthrax disease Adults: 120 mg orally twice daily for 60 days. Pediatric <45 kg: 2.6 mg/kg orally twice daily for 60 days; >=45 kg: adult dose.
Malaria Adults: 120 mg once daily. Pediatric >=8 years: 2.4 mg/kg once daily; >=45 kg: adult dose. Begin 1-2 days before travel, continue during travel, and for 4 weeks after leaving the malarious area.
Contraindications
- Known serious hypersensitivity to ceftazidime, avibactam, avibactam-containing products, or other members of the cephalosporin class
- Hypersensitivity to any of the tetracyclines
Adverse Reactions
Most common (>=5%) Diarrhea, nausea, vomiting (cIAI); diarrhea, vomiting (HABP/VABP); nausea, diarrhea (cUTI)
Serious Hypersensitivity reactions, Clostridioides difficile-associated diarrhea, central nervous system reactions (including seizures, encephalopathy), increased mortality in patients with moderate renal impairment (CrCl 30-50 mL/min) if underdosed
Postmarketing Colitis, toxic nephropathy, hepatic dysfunction including cholestasis, hemorrhage, pancytopenia, aplastic anemia, prolonged prothrombin time, false-positive urinary glucose, acute myocardial ischemia
Gastrointestinal Anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, pancreatitis, esophagitis, esophageal ulcerations
Skin Maculopapular rashes, erythematous rashes, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, erythema multiforme, fixed drug eruption, photosensitivity
Hypersensitivity Urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis, exacerbation of systemic lupus erythematosus
Hematologic Hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia
Neurologic/Psychiatric Intracranial hypertension (pseudotumor cerebri), depression, anxiety, suicidal ideation, insomnia, abnormal dreams, hallucination
Renal Rise in BUN (dose-related)
Thyroid Brown-black microscopic discoloration of thyroid glands with prolonged use; no known thyroid function abnormalities
Pharmacology
Ceftazidime is a cephalosporin that exerts bactericidal activity by binding penicillin-binding proteins of susceptible gram-negative bacteria; avibactam is a non-beta-lactam beta-lactamase inhibitor that inactivates certain beta-lactamases (including KPCs, ESBLs, and AmpC enzymes) that would otherwise degrade ceftazidime, thereby restoring ceftazidime activity against resistant organisms.
Doxycycline is a tetracycline-class antimicrobial that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, exerting bacteriostatic activity against a broad range of Gram-positive and Gram-negative bacteria.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Avycaz
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (6/12) · Qty limit (0/12)
Doryx Mpc
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (9/12) · Qty limit (0/12)
UnitedHealthcare
Avycaz
- Covered on 4 commercial plans
- PA (1/8) · Step Therapy (0/8) · Qty limit (0/8)
Doryx Mpc
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (6/8) · Qty limit (0/8)
Humana
Avycaz
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Doryx Mpc
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableHealthWell: Cystic Fibrosis Treatments
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
No savings programs available for Doryx Mpc.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.