| Urinary tract infection
Avycaz vs Targadox
Side-by-side clinical, coverage, and cost comparison for urinary tract infection.Deep comparison between: Avycaz vs Targadox with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTargadox has a higher rate of injection site reactions vs Avycaz based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Targadox but not Avycaz, including UnitedHealthcare
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Category
Avycaz
Targadox
At A Glance
IV infusion
Every 8 hours
Cephalosporin/beta-lactamase inhibitor
Oral
Daily to twice daily
Tetracycline antibiotic
Indications
- Urinary Tract Infection
- Pneumonia, Bacterial
- Rocky Mountain Spotted Fever
- TYPHUS
- Q Fever
- Rickettsialpox
- Respiratory Tract Infections
- Respiratory Tract Infections
- Upper Respiratory Infections
- Urinary tract infection
- Lymphogranuloma Venereum
- Psittacosis
- Trachoma
- Inclusion conjunctivitis
- Urethritis
- Uterine Cervicitis
- Proctitis
- non-gonococcal urethritis (NGU)
- Relapsing Fever
- Chancroid
- Plague
- Tularemia
- Cholera
- Campylobacter infection
- Brucellosis
- Bartonella Infections
- Granuloma Inguinale
- Anthrax disease
- Gonorrhea
- Syphilis
- Yaws
- Listeriosis
- Necrotizing Ulcerative Gingivitis
- Actinomycosis
- Clostridium Infections
- Amebiasis
- Acne Vulgaris
- Malaria
Dosing
Complicated Intra-abdominal Infections, Urinary Tract Infection, Pneumonia, Bacterial 2.5 grams (ceftazidime 2 grams and avibactam 0.5 grams) IV every 8 hours infused over 2 hours in adults with CrCl > 50 mL/min; cIAI requires concurrent metronidazole; dosage adjustment required for CrCl <=50 mL/min; duration 5-14 days (cIAI) or 7-14 days (cUTI, HABP/VABP).
Adults (general infections) 200 mg on day 1 (100 mg every 12 hours), then 100 mg/day maintenance; 100 mg every 12 hours for severe or chronic Urinary tract infection.
Pediatric patients <45 kg (severe infections) 2.2 mg/kg every 12 hours; for less severe disease (>8 years, <45 kg): 4.4 mg/kg divided into two doses on day 1, then 2.2 mg/kg/day as a single or divided dose. Children >=45 kg receive the adult dose.
Gonorrhea 100 mg twice daily for 7 days; alternate single-visit dose: 300 mg followed by 300 mg 1 hour later, may be taken with food or beverage.
Urethritis, Uterine Cervicitis, Proctitis, non-gonococcal urethritis (NGU) 100 mg twice daily for 7 days.
Syphilis (early, penicillin-allergic patients) 100 mg twice daily for 2 weeks.
Syphilis (>1 year duration, penicillin-allergic patients) 100 mg twice daily for 4 weeks.
Malaria (prophylaxis) Adults: 100 mg once daily beginning 1-2 days before travel, continuing during travel, and for 4 weeks after leaving the malarious area. Pediatric patients >8 years: 2 mg/kg once daily up to the adult dose.
Anthrax disease (inhalational, post-exposure) Adults: 100 mg twice daily for 60 days. Children <45 kg: 2.2 mg/kg twice daily for 60 days; children >=45 kg receive the adult dose.
Contraindications
- Known serious hypersensitivity to ceftazidime, avibactam, avibactam-containing products, or other members of the cephalosporin class
- Hypersensitivity to any of the tetracyclines
Adverse Reactions
Most common (>=5%) Diarrhea, nausea, vomiting (cIAI); diarrhea, vomiting (HABP/VABP); nausea, diarrhea (cUTI)
Serious Hypersensitivity reactions, Clostridioides difficile-associated diarrhea, central nervous system reactions (including seizures, encephalopathy), increased mortality in patients with moderate renal impairment (CrCl 30-50 mL/min) if underdosed
Postmarketing Colitis, toxic nephropathy, hepatic dysfunction including cholestasis, hemorrhage, pancytopenia, aplastic anemia, prolonged prothrombin time, false-positive urinary glucose, acute myocardial ischemia
Most common Nausea, vomiting, diarrhea, anorexia, glossitis, dysphagia, enterocolitis, maculopapular and erythematous rashes.
Serious Toxic epidermal necrolysis, Stevens-Johnson syndrome, anaphylaxis, anaphylactoid purpura, DRESS, intracranial hypertension, hemolytic anemia, thrombocytopenia, hepatotoxicity, esophagitis, esophageal ulceration, permanent tooth discoloration.
Pharmacology
Ceftazidime is a cephalosporin that exerts bactericidal activity by binding penicillin-binding proteins of susceptible gram-negative bacteria; avibactam is a non-beta-lactam beta-lactamase inhibitor that inactivates certain beta-lactamases (including KPCs, ESBLs, and AmpC enzymes) that would otherwise degrade ceftazidime, thereby restoring ceftazidime activity against resistant organisms.
Tetracycline-class antibacterial; doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, exhibiting bacteriostatic activity against a broad range of Gram-positive and Gram-negative bacteria.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Avycaz
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (6/12) · Qty limit (0/12)
Targadox
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (9/12) · Qty limit (10/12)
UnitedHealthcare
Avycaz
- Covered on 4 commercial plans
- PA (1/8) · Step Therapy (0/8) · Qty limit (0/8)
Targadox
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Avycaz
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Targadox
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (2/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableHealthWell: Cystic Fibrosis Treatments
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
No savings programs available for Targadox.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.