| Urinary tract infection
Avycaz vs Zemdri
Side-by-side clinical, coverage, and cost comparison for urinary tract infection.Deep comparison between: Avycaz vs Zemdri (Plazomicin) with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsZemdri (Plazomicin) has a higher rate of injection site reactions vs Avycaz based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Zemdri (Plazomicin) but not Avycaz, including UnitedHealthcare
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Category
Avycaz
Zemdri (Plazomicin)
At A Glance
IV infusion
Every 8 hours
Cephalosporin/beta-lactamase inhibitor
IV infusion
Every 24 hours
Aminoglycoside
Indications
- Urinary Tract Infection
- Pneumonia, Bacterial
- Urinary tract infection
Dosing
Complicated Intra-abdominal Infections, Urinary Tract Infection, Pneumonia, Bacterial 2.5 grams (ceftazidime 2 grams and avibactam 0.5 grams) IV every 8 hours infused over 2 hours in adults with CrCl > 50 mL/min; cIAI requires concurrent metronidazole; dosage adjustment required for CrCl <=50 mL/min; duration 5-14 days (cIAI) or 7-14 days (cUTI, HABP/VABP).
Urinary tract infection 15 mg/kg every 24 hours by IV infusion over 30 minutes for 4 to 7 days in adults with CLcr >=90 mL/min; dose reduced to 10 mg/kg every 24 hours (CLcr 30 to <90 mL/min) or 10 mg/kg every 48 hours (CLcr 15 to <30 mL/min).
Contraindications
- Known serious hypersensitivity to ceftazidime, avibactam, avibactam-containing products, or other members of the cephalosporin class
- Known hypersensitivity to any aminoglycoside
Adverse Reactions
Most common (>=5%) Diarrhea, nausea, vomiting (cIAI); diarrhea, vomiting (HABP/VABP); nausea, diarrhea (cUTI)
Serious Hypersensitivity reactions, Clostridioides difficile-associated diarrhea, central nervous system reactions (including seizures, encephalopathy), increased mortality in patients with moderate renal impairment (CrCl 30-50 mL/min) if underdosed
Postmarketing Colitis, toxic nephropathy, hepatic dysfunction including cholestasis, hemorrhage, pancytopenia, aplastic anemia, prolonged prothrombin time, false-positive urinary glucose, acute myocardial ischemia
Most common (>=1%) Decreased renal function, diarrhea, hypertension, headache, nausea, vomiting, hypotension
Serious Nephrotoxicity, ototoxicity, neuromuscular blockade, fetal harm, hypersensitivity reactions, Clostridium difficile-associated diarrhea
Pharmacology
Ceftazidime is a cephalosporin that exerts bactericidal activity by binding penicillin-binding proteins of susceptible gram-negative bacteria; avibactam is a non-beta-lactam beta-lactamase inhibitor that inactivates certain beta-lactamases (including KPCs, ESBLs, and AmpC enzymes) that would otherwise degrade ceftazidime, thereby restoring ceftazidime activity against resistant organisms.
Plazomicin is an aminoglycoside antibacterial that binds to the bacterial 30S ribosomal subunit, inhibiting protein synthesis with concentration-dependent bactericidal activity against Enterobacteriaceae.
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Most Common Insurance
Anthem BCBS
Avycaz
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (6/12) · Qty limit (0/12)
Zemdri (Plazomicin)
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (5/12) · Qty limit (0/12)
UnitedHealthcare
Avycaz
- Covered on 4 commercial plans
- PA (1/8) · Step Therapy (0/8) · Qty limit (0/8)
Zemdri (Plazomicin)
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Avycaz
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Zemdri (Plazomicin)
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableHealthWell: Cystic Fibrosis Treatments
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
No savings programs available for Zemdri (Plazomicin).
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AvycazView full Avycaz profile
Zemdri (Plazomicin)View full Zemdri (Plazomicin) profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.