| Urinary tract infection
Zemdri vs Avycaz
Side-by-side clinical, coverage, and cost comparison for urinary tract infection.Deep comparison between: Zemdri (Plazomicin) vs Avycaz with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsAvycaz has a higher rate of injection site reactions vs Zemdri (Plazomicin) based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Avycaz but not Zemdri (Plazomicin), including UnitedHealthcare
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Category
Zemdri (Plazomicin)
Avycaz
At A Glance
IV infusion
Every 24 hours
Aminoglycoside
IV infusion
Every 8 hours
Cephalosporin/beta-lactamase inhibitor
Indications
- Urinary tract infection
- Urinary Tract Infection
- Pneumonia, Bacterial
Dosing
Urinary tract infection 15 mg/kg every 24 hours by IV infusion over 30 minutes for 4 to 7 days in adults with CLcr >=90 mL/min; dose reduced to 10 mg/kg every 24 hours (CLcr 30 to <90 mL/min) or 10 mg/kg every 48 hours (CLcr 15 to <30 mL/min).
Complicated Intra-abdominal Infections, Urinary Tract Infection, Pneumonia, Bacterial 2.5 grams (ceftazidime 2 grams and avibactam 0.5 grams) IV every 8 hours infused over 2 hours in adults with CrCl > 50 mL/min; cIAI requires concurrent metronidazole; dosage adjustment required for CrCl <=50 mL/min; duration 5-14 days (cIAI) or 7-14 days (cUTI, HABP/VABP).
Contraindications
- Known hypersensitivity to any aminoglycoside
- Known serious hypersensitivity to ceftazidime, avibactam, avibactam-containing products, or other members of the cephalosporin class
Adverse Reactions
Most common (>=1%) Decreased renal function, diarrhea, hypertension, headache, nausea, vomiting, hypotension
Serious Nephrotoxicity, ototoxicity, neuromuscular blockade, fetal harm, hypersensitivity reactions, Clostridium difficile-associated diarrhea
Most common (>=5%) Diarrhea, nausea, vomiting (cIAI); diarrhea, vomiting (HABP/VABP); nausea, diarrhea (cUTI)
Serious Hypersensitivity reactions, Clostridioides difficile-associated diarrhea, central nervous system reactions (including seizures, encephalopathy), increased mortality in patients with moderate renal impairment (CrCl 30-50 mL/min) if underdosed
Postmarketing Colitis, toxic nephropathy, hepatic dysfunction including cholestasis, hemorrhage, pancytopenia, aplastic anemia, prolonged prothrombin time, false-positive urinary glucose, acute myocardial ischemia
Pharmacology
Plazomicin is an aminoglycoside antibacterial that binds to the bacterial 30S ribosomal subunit, inhibiting protein synthesis with concentration-dependent bactericidal activity against Enterobacteriaceae.
Ceftazidime is a cephalosporin that exerts bactericidal activity by binding penicillin-binding proteins of susceptible gram-negative bacteria; avibactam is a non-beta-lactam beta-lactamase inhibitor that inactivates certain beta-lactamases (including KPCs, ESBLs, and AmpC enzymes) that would otherwise degrade ceftazidime, thereby restoring ceftazidime activity against resistant organisms.
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Most Common Insurance
Anthem BCBS
Zemdri (Plazomicin)
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (5/12) · Qty limit (0/12)
Avycaz
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (6/12) · Qty limit (0/12)
UnitedHealthcare
Zemdri (Plazomicin)
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Avycaz
- Covered on 4 commercial plans
- PA (1/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Zemdri (Plazomicin)
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Avycaz
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Zemdri (Plazomicin).
Cost estimate not availableHealthWell: Cystic Fibrosis Treatments
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Zemdri (Plazomicin)View full Zemdri (Plazomicin) profile
AvycazView full Avycaz profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.