| Urinary tract infection
Zerbaxa vs Doryx MPC
Side-by-side clinical, coverage, and cost comparison for urinary tract infection.Deep comparison between: Zerbaxa vs Doryx Mpc with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsDoryx Mpc has a higher rate of injection site reactions vs Zerbaxa based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Doryx Mpc but not Zerbaxa, including UnitedHealthcare
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Category
Zerbaxa
Doryx Mpc
At A Glance
IV infusion
Every 8 hours
Cephalosporin/beta-lactamase inhibitor
Oral
Once or twice daily
Tetracycline antibiotic
Indications
- Peritonitis
- Urinary tract infection
- Pyelonephritis
- Hospital acquired pneumonia
- VABP
- Rocky Mountain Spotted Fever
- TYPHUS
- Q Fever
- Rickettsialpox
- non-gonococcal urethritis (NGU)
- Lymphogranuloma Venereum
- Granuloma Inguinale
- Gonorrhea
- Chancroid
- Psittacosis
- Respiratory Tract Infections
- Upper Respiratory Infections
- Relapsing Fever
- Plague
- Tularemia
- Cholera
- Brucellosis
- Bartonella Infections
- Trachoma
- Inclusion conjunctivitis
- Anthrax disease
- Syphilis
- Yaws
- Listeriosis
- Necrotizing Ulcerative Gingivitis
- Actinomycosis
- Amebiasis
- Acne Vulgaris
- Malaria
- Urethritis
- Uterine Cervicitis
- Proctitis
- Urinary tract infection
Dosing
Peritonitis 1.5 g IV every 8 hours over 1 hour for 4 to 14 days, used in conjunction with metronidazole 500 mg IV every 8 hours; pediatric patients: 30 mg/kg up to 1.5 g every 8 hours for 5 to 14 days.
Urinary tract infection, Pyelonephritis 1.5 g IV every 8 hours over 1 hour for 7 days; pediatric patients: 30 mg/kg up to 1.5 g every 8 hours for 7 to 14 days.
Hospital acquired pneumonia, VABP 3 g IV every 8 hours over 1 hour for 8 to 14 days in adult patients 18 years and older.
Rocky Mountain Spotted Fever, TYPHUS, Q Fever, Rickettsialpox, Relapsing Fever, Plague, Tularemia, Cholera, Brucellosis, Bartonella Infections, Psittacosis, Respiratory Tract Infections, Upper Respiratory Infections, Trachoma, Inclusion conjunctivitis, Yaws, Listeriosis, Necrotizing Ulcerative Gingivitis, Actinomycosis, Amebiasis, Acne Vulgaris, Urinary tract infection Adults: 240 mg on day 1 (120 mg every 12 hours), then 120 mg daily maintenance; for severe infections (e.g., chronic urinary tract infections), 120 mg every 12 hours. Pediatric <45 kg (>8 years, less severe disease): 5.3 mg/kg divided in 2 doses on day 1, then 2.6 mg/kg daily; severe or life-threatening infections: 2.6 mg/kg every 12 hours. Pediatric >=45 kg: adult dose.
non-gonococcal urethritis (NGU), Urethritis, Uterine Cervicitis, Proctitis 120 mg orally twice daily for 7 days.
Gonorrhea 120 mg orally twice daily for 7 days; alternate single-visit dose: 360 mg followed in 1 hour by a second 360 mg dose.
Syphilis (early, penicillin allergy) 120 mg orally twice daily for 2 weeks.
Syphilis (>1 year duration, penicillin allergy) 120 mg orally twice daily for 4 weeks.
Anthrax disease Adults: 120 mg orally twice daily for 60 days. Pediatric <45 kg: 2.6 mg/kg orally twice daily for 60 days; >=45 kg: adult dose.
Malaria Adults: 120 mg once daily. Pediatric >=8 years: 2.4 mg/kg once daily; >=45 kg: adult dose. Begin 1-2 days before travel, continue during travel, and for 4 weeks after leaving the malarious area.
Contraindications
- Known serious hypersensitivity to components of ZERBAXA (ceftolozane and tazobactam), piperacillin/tazobactam, or other members of the beta-lactam class
- Hypersensitivity to any of the tetracyclines
Adverse Reactions
Most common (>=5%) Nausea, diarrhea, headache, pyrexia
Serious Hypersensitivity reactions, Clostridioides difficile-associated diarrhea, intracranial hemorrhage, renal impairment/renal failure, hepatic transaminase increased
Gastrointestinal Anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, pancreatitis, esophagitis, esophageal ulcerations
Skin Maculopapular rashes, erythematous rashes, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, erythema multiforme, fixed drug eruption, photosensitivity
Hypersensitivity Urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis, exacerbation of systemic lupus erythematosus
Hematologic Hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia
Neurologic/Psychiatric Intracranial hypertension (pseudotumor cerebri), depression, anxiety, suicidal ideation, insomnia, abnormal dreams, hallucination
Renal Rise in BUN (dose-related)
Thyroid Brown-black microscopic discoloration of thyroid glands with prolonged use; no known thyroid function abnormalities
Pharmacology
Ceftolozane is a cephalosporin antibacterial that inhibits bacterial cell wall biosynthesis by binding to penicillin-binding proteins (PBPs); tazobactam is an irreversible beta-lactamase inhibitor that extends ceftolozane activity against beta-lactamase-producing organisms.
Doxycycline is a tetracycline-class antimicrobial that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, exerting bacteriostatic activity against a broad range of Gram-positive and Gram-negative bacteria.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Zerbaxa
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (6/12) · Qty limit (0/12)
Doryx Mpc
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (9/12) · Qty limit (0/12)
UnitedHealthcare
Zerbaxa
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Doryx Mpc
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (6/8) · Qty limit (0/8)
Humana
Zerbaxa
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Doryx Mpc
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Zerbaxa.
No savings programs available for Doryx Mpc.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.