| Uveitis

Iluvien vs Ozurdex

Side-by-side clinical, coverage, and cost comparison for uveitis.

Deep comparison between: Iluvien vs Ozurdex with Prescriber.AI

AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.

Safety signalsOzurdex has a higher rate of injection site reactions vs Iluvien based on FDA-approved prescribing information

Coverage gaps3 major payers require step therapy for Ozurdex but not Iluvien, including UnitedHealthcare

Category

Iluvien

Ozurdex

At A Glance

RouteIntravitreal injection

ClassCorticosteroid

RouteIntravitreal injection

ClassCorticosteroid

Indications

Diabetic Retinopathy
Uveitis

Macular retinal edema
Uveitis

Dosing

Diabetic Retinopathy, Uveitis Single 0.19 mg (190 mcg) fluocinolone acetonide intravitreal implant injected under aseptic conditions via a preloaded single-use applicator; optimal placement is inferior to the optic disc and posterior to the equator, with needle entry 4 mm inferotemporal from the limbus.

Macular retinal edema, Uveitis One 0.7 mg intravitreal implant injected into the vitreous cavity under controlled aseptic conditions; each applicator is single-use and treats one eye only.

Contraindications

Active or suspected ocular or periocular infections, including active epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, varicella, mycobacterial infections, and fungal diseases
Glaucoma with cup to disc ratio greater than 0.8
Known hypersensitivity to any components of ILUVIEN

Active or suspected ocular or periocular infections, including viral diseases of the cornea and conjunctiva (active epithelial herpes simplex keratitis, vaccinia, varicella), mycobacterial infections, and fungal diseases
Glaucoma with cup to disc ratios greater than 0.8
Torn or ruptured posterior lens capsule due to risk of migration into the anterior chamber
Known hypersensitivity to any components of this product

Drug Interactions

965View drug interactions

1320View drug interactions

Adverse Reactions

Most common (>=1%) Cataract, increased intraocular pressure, myodesopsia, eye pain, conjunctival haemorrhage, posterior capsule opacification, eye irritation, vitreous detachment, conjunctivitis, corneal oedema, ocular hyperaemia, anemia, headache, renal failure, pneumonia

Serious Optic nerve damage, visual acuity and field defects, secondary ocular infections including herpes simplex, perforation of the globe where there is thinning of the cornea or sclera

Postmarketing Drug administration error, drug ineffectiveness

Most common (>=20%) Cataract, increased intraocular pressure, conjunctival hemorrhage

Serious Elevated IOP with optic nerve damage, visual acuity and field defects, posterior subcapsular cataract formation, secondary ocular infection (including herpes simplex), globe perforation

Postmarketing Endophthalmitis, retinal detachment, implant misplacement with ocular tissue injury, device dislocation with corneal edema or decompensation, hypotony of the eye

Pharmacology

Fluocinolone acetonide is a synthetic corticosteroid that inhibits inflammatory responses by blocking phospholipase A2 via lipocortins, suppressing biosynthesis of prostaglandins and leukotrienes and reducing edema, leukocyte migration, capillary proliferation, and fibroblast proliferation.

Dexamethasone is a corticosteroid that suppresses inflammation by inhibiting multiple inflammatory cytokines, resulting in decreased edema, fibrin deposition, capillary leakage, and migration of inflammatory cells.

View Full FDA Information

View full FDA information

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Most Common Insurance

Anthem BCBS

Iluvien