Microtubule Inhibitor

Breast Neoplasms

Carcinoma, Non-Small-Cell Lung

Ovarian Neoplasms

Sarcoma, Kaposi

<section class="Section" data-sectioncode="34089-3"><a name="KS1104c55f3fb-c4cf-11df-851a-0800200c9a66"></a><a name="section-11"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">ABRAXANE for Injectable Suspension (paclitaxel protein-bound particles for injectable suspension) (albumin-bound) is paclitaxel formulated as albumin-bound nanoparticles with a mean particle size of approximately 130 nanometers. Paclitaxel exists in the particles in a non-crystalline, amorphous state. Paclitaxel is a microtubule inhibitor. The chemical name for paclitaxel is 5β,20-Epoxy-1,2α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2<span class="Italics">R</span>,3<span class="Italics">S</span>)-<span class="Italics">N</span>-benzoyl-3-phenylisoserine. The empirical formula is C<span class="Sub">47</span>H<span class="Sub">51</span>NO<span class="Sub">14</span> and the molecular weight is 853.91. Paclitaxel has the following structural formula:</p><div class="Figure"><a name="id2234"></a><img alt="Structural Formula for Paclitaxel" src="abraxane-02.jpg"/></div><p>Paclitaxel is a white to off-white crystalline powder. It is highly lipophilic, insoluble in water, and melts at approximately 216°C to 217°C.</p><p>ABRAXANE is supplied as a white to yellow, sterile, lyophilized powder for reconstitution with 20 mL of 0.9% Sodium Chloride Injection, USP prior to intravenous infusion. Each single‑dose vial contains 100 mg of paclitaxel (bound to human albumin) and approximately 900 mg of human albumin (containing sodium caprylate and sodium acetyltryptophanate). Each milliliter (mL) of reconstituted suspension contains 5 mg paclitaxel formulated as albumin‑bound particles. ABRAXANE is free of solvents.</p></section>

ABRAXANE

paclitaxel

paclitaxel 100 MG Injection

paclitaxel 100 MG Injection [Abraxane]

Abraxane

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Report Adverse Event 

Prescribing Information 

Medication Guide 

Submit MSL Request 

Pharmacy List 

Billing & Coding Guide 

Reimbursement Information 

Formulary Information 

Coverage Authorization Request 

Commercial Claim Denial Appeal/Redetermination Letter

Letter of Medical Necessity 

Medically Unlikely Edit (MUE) Letter

Abraxane Enrollment Form 

Abraxane Enrollment Form - Spanish 

Coverage Authorization Appeals 

Enroll in Patient Savings Program 

Other HCP Resources - Forms 

Other HCP Resources 

Instructions For Use: Metastatic Pancreatic Cancer 

About Abraxane: Metastatic Pancreatic Cancer 

Receiving Abraxane: Metastatic Pancreatic Cancer 

Side Effects: Metastatic Pancreatic Cancer 

Patient Resources: Metastatic Pancreatic Cancer 

Instructions For Use: Metastatic Breast Cancer 

About Abraxane: Metastatic Breast Cancer 

Receiving Abraxane: Metastatic Breast Cancer 

Side Effects: Metastatic Breast Cancer 

Patient Resources: Metastatic Breast Cancer 

About Abraxane: 1L Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

Receiving Abraxane: 1L Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

Side Effects: 1L Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

Patient Resources: 1L Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

Instructions For Use: 1L Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

Abraxane Cost Information 

Preparing For Treatment Brochure 

My BMS Cases: Access Online Portal 