Dopamine Agonists

Dopaminergic Agonist

Parkinson Disease

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-11"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">APOKYN (apomorphine hydrochloride injection) contains apomorphine hydrochloride, a non-ergoline dopamine agonist. Apomorphine hydrochloride is chemically designated as 6aβ-Aporphine-10,11-diol hydrochloride hemihydrate with a molecular formula of C          <span class="Sub">17</span>H          <span class="Sub">17</span>NO          <span class="Sub">2</span> ∙ HCl ∙ ½ H          <span class="Sub">2</span>O. Its structural formula and molecular weight are:       </p><table class="Noautorules" width="100%"><col align="center" valign="top" width="100%"/><tbody class="Headless"><tr><td align="center"><span class="Bold">Figure 1: Structural Formula and Molecular Weight of Apomorphine</span></td></tr><tr><td align="center"><img alt="Figure 1" src="apokyn-01.jpg"/></td></tr><tr><td align="center">M.W. 312.79</td></tr></tbody></table><p>Apomorphine hydrochloride appears as minute, white or grayish-white glistening crystals or as white powder that is soluble in water at 80°C.</p><p>APOKYN is a clear, colorless, sterile solution for subcutaneous injection and is available in 3 mL (30 mg) multi-dose cartridges. Each mL of solution contains 10 mg of apomorphine hydrochloride, USP as apomorphine hydrochloride hemihydrate (equivalent to 8.55 mg apomorphine), 1 mg of sodium metabisulfite, NF and 5 mg of benzyl alcohol, NF (preservative) in water for injection, USP. In addition, each mL of solution may contain sodium hydroxide, NF and/or hydrochloric acid, NF to adjust the pH of the solution.</p></section>

APOKYN

apomorphine

Apokyn

apomorphine hydrochloride

3 ML apomorphine hydrochloride 10 MG/ML Cartridge

3 ML apomorphine hydrochloride 10 MG/ML Cartridge [Apokyn]

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Apokyn mimics the actions of dopamine, a naturally occurring chemical in the body. Reduced dopamine levels in the brain are linked to Parkinson's disease.

Apokyn is a prescribed medication employed to manage "wearing-off" episodes, characterized by muscle stiffness and loss of muscle control, in individuals with advanced Parkinson's disease.

The safety and effectiveness of Apokyn in children remain uncertain.