Tyrosine Kinase Inhibitors

Kinase Inhibitor

P-Glycoprotein Inhibitors

Cytochrome P450 2C9 Inhibitors

Breast Cancer Resistance Protein Inhibitors

Multidrug and Toxin Extrusion Transporter 1 Inhibitors

Bile Salt Export Pump Inhibitors

Multidrug and Toxin Extrusion Transporter 2 K Inhibitors

Gastrointestinal Stromal Tumors

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-9"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">Avapritinib is a kinase inhibitor with the chemical name (<span class="Italics">S</span>)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1<span class="Italics">H</span>-pyrazol-4-yl)pyrrolo[2,1-<span class="Italics">f</span>][1,2,4]triazin-4-yl)piperazin-yl)pyrimidin-5-yl)ethan-1-amine. The molecular formula is C<span class="Sub">26</span>H<span class="Sub">27</span>FN<span class="Sub">10</span>, and the molecular weight is 498.57 g/mol. Avapritinib has the following chemical structure:</p><div class="Figure"><img alt="Chemical Structure" src="ayvakit-01.jpg"/></div><p>The solubility of avapritinib in 0.1N HCl (pH 1.0) and buffer solutions at pH 2.5, 4.0, and 7.0 (at 25°C) is 3.6 mg/mL, 0.14 mg/mL, 0.07 mg/mL and &lt;0.001 mg/mL respectively, indicating a decrease in solubility with increasing pH.</p><p>AYVAKIT (avapritinib) film-coated tablets for oral use are supplied with five strengths that contain 25 mg, 50 mg, 100 mg, 200 mg or 300 mg of avapritinib. The tablets also contain inactive ingredients: copovidone, croscarmellose sodium, magnesium stearate, and microcrystalline cellulose. The tablet coating consists of polyethylene glycol, polyvinyl alcohol, talc, and titanium dioxide. The blue printing ink, used only for avapritinib 100 mg, 200 mg and 300 mg strength tablets, contains ammonium hydroxide, black iron oxide, esterified shellac, FD&amp;C blue 1, isopropyl alcohol, n-butyl alcohol, propylene glycol, and titanium dioxide.</p></section>

Ayvakit

avapritinib

avapritinib 100 MG Oral Tablet

avapritinib 100 MG Oral Tablet [Ayvakit]

avapritinib 200 MG Oral Tablet

avapritinib 200 MG Oral Tablet [Ayvakit]

avapritinib 300 MG Oral Tablet

avapritinib 300 MG Oral Tablet [Ayvakit]

avapritinib 25 MG Oral Tablet

avapritinib 25 MG Oral Tablet [Ayvakit]

avapritinib 50 MG Oral Tablet

avapritinib 50 MG Oral Tablet [Ayvakit]

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

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Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Report Adverse Event 

Prescribing Information 

Medication Guide 

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Pharmacy List 

Reimbursement Information 

Ayvakit Enrollment Form 

Ayvakit Dose Exchange Form 

Access & Reimbursement Guide 

Letter of Medical Necessity

Coverage Authorization Appeals

Coverage Authorization Request 

Formulary Exception Request 

Enroll in Patient Savings Program 

Enroll in Bridge Program 

Coverage Interruption Program 

Your Blueprint Brochure - Financial Access

About Ayvakit: Advanced Systemic Mastocytosis (AdvSM)

Patient Brochure: Advanced Systemic Mastocytosis (AdvSM)

Taking Avyakit: Advanced Systemic Mastocytosis (AdvSM)

Instructions For Use: Advanced Systemic Mastocytosis (AdvSM)

Other HCP Resources: Advanced Systemic Mastocytosis (AdvSM)

Patient Brochure: Gastrointestinal Stromal Tumor (GIST)

Instructions For Use: Gastrointestinal Stromal Tumor (GIST)

Patient Resources:  Gastrointestinal Stromal Tumor (GIST)

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