Bcr-Abl Tyrosine Kinase Inhibitors

Kinase Inhibitor

Leukemia, Myelogenous, Chronic, BCR-ABL Positive

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-10"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">BOSULIF contains bosutinib, a kinase inhibitor. Bosutinib is present as a monohydrate with a chemical name of 3-Quinolinecarbonitrile, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl) propoxy]-, hydrate (1:1). Its chemical formula is C<span class="Sub">26</span>H<span class="Sub">29</span>Cl<span class="Sub">2</span>N<span class="Sub">5</span>O<span class="Sub">3</span>∙H<span class="Sub">2</span>O (monohydrate); its molecular weight is 548.46 (monohydrate), equivalent to 530.46 (anhydrous). Bosutinib monohydrate has the following chemical structure: </p><div class="Figure"><a name="id2278"></a><img alt="Chemical Structure" src="bosulif-01.jpg"/></div><p>Bosutinib monohydrate is a white to yellowish-tan powder. Bosutinib monohydrate has a pH dependent solubility across the physiological pH range. At or below pH 5, bosutinib monohydrate behaves as a highly soluble compound. Above pH 5, the solubility of bosutinib monohydrate reduces rapidly.</p><p>BOSULIF<span class="Sup">®</span> (bosutinib) tablets are supplied for oral administration in 3 strengths: 100 mg, 400 mg and 500 mg. Each strength reflects the equivalent amount of bosutinib content (on anhydrous basis). The tablets contain the following inactive ingredients: croscarmellose sodium, iron oxide red (for 400 mg, and 500 mg tablet) and iron oxide yellow (for 100 mg, and 400 mg tablet), magnesium stearate, microcrystalline cellulose, poloxamer, polyethylene glycol, polyvinyl alcohol, povidone, talc and titanium dioxide. </p><p>BOSULIF<span class="Sup">®</span> (bosutinib) capsules are supplied for oral administration in 2 strengths: 50 mg and 100 mg. Each strength reflects the equivalent amount of bosutinib (on anhydrous basis). The capsules contain the following inactive ingredients: croscarmellose sodium, gelatin, magnesium stearate, mannitol, microcrystalline cellulose, poloxamer, povidone, red iron oxide, titanium dioxide, yellow iron oxide. The printing ink contains black iron oxide, potassium hydroxide, propylene glycol, shellac, strong ammonia solution.</p></section>

BOSULIF

bosutinib

bosutinib 100 MG Oral Tablet

Bosulif

bosutinib 100 MG Oral Tablet [Bosulif]

bosutinib 500 MG Oral Tablet

bosutinib 500 MG Oral Tablet [Bosulif]

bosutinib 400 MG Oral Tablet

bosutinib 400 MG Oral Tablet [Bosulif]

bosutinib 100 MG Oral Capsule

bosutinib 50 MG Oral Capsule

bosutinib 100 MG Oral Capsule [Bosulif]

bosutinib 50 MG Oral Capsule [Bosulif]

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Report Adverse Event 

Prescribing Information 

Medication Guide 

Submit MSL Request 

Pharmacy List 

Reimbursement Information 

Coverage Authorization Request 

Coverage Authorization Appeal

Letter of Medical Necessity

Formulary Exception Letter

Appeals Checklist 

PA Checklist 

Appeals Checklsit 

Other HCP Resources: Access

Pfizer Oncology Together Form 

Pfizer Oncology Together Form - Spanish 

Enroll in Patient Savings Program 

Pfizer Patient Assistance Program 

Free 90-day Supply: For Uninsured Patients While Applying for Medicaid

HCP Office : Attest & Print Co-Pay Card 

Pfizer Oncology Patient Access Guide 

Pfizer Oncology Patient Access Guide - Spanish 

Instructions For Use: Adults with CP Ph+ CML

Instructions For Use: Ph+ CML in Adults With Resistance or Intolerance to Prior Therapy