Interleukin-17A Antagonists

Interleukin-17A Antagonist

Spondylitis, Ankylosing

Arthritis, Psoriatic

<section class="Section" data-sectioncode="34089-3"><a name="section-10"></a><h1>11     DESCRIPTION</h1>Secukinumab, a recombinant human monoclonal IgG1/κ antibody, is an interleukin-17A antagonist. It is expressed in a recombinant Chinese Hamster Ovary (CHO) cell line. Secukinumab has a molecular mass of approximately 151 kDa; both heavy chains of secukinumab contain oligosaccharide chains.COSENTYX Injection for Subcutaneous UseCOSENTYX injection is a sterile, preservative-free, clear to slightly opalescent, colorless to slightly yellow solution for subcutaneous use. COSENTYX injection is supplied in a single-dose 300 mg/2 mL UnoReady pen with a 27-gauge fixed ½-inch needle, a single-dose 150 mg/mL Sensoready pen with a 27-gauge fixed ½-inch needle, or a single-dose prefilled syringe (300 mg/2 mL, 150 mg/mL, 75 mg/0.5 mL) with a 27-gauge fixed ½-inch needle. The removable cap of the COSENTYX 150 mg/mL Sensoready pen or 1 mL and 0.5 mL prefilled syringes contains natural rubber latex.Each COSENTYX 300 mg/2 mL UnoReady pen or 300 mg/2 mL prefilled syringe contains 300 mg of secukinumab formulated in: L-histidine/histidine hydrochloride monohydrate (6.206 mg), L-methionine (1.492 mg), polysorbate 80 (0.4 mg), trehalose dihydrate (151.34 mg), and Sterile Water for Injection, USP, at pH of 5.8.Each COSENTYX 150 mg/mL Sensoready pen or 150 mg/mL prefilled syringe contains 150 mg of secukinumab formulated in: L-histidine/histidine hydrochloride monohydrate (3.103 mg), L-methionine (0.746 mg), polysorbate 80 (0.2 mg), trehalose dihydrate (75.67 mg), and Sterile Water for Injection, USP, at pH of 5.8.Each COSENTYX 75 mg/0.5 mL prefilled syringe contains 75 mg of secukinumab formulated in: L-histidine/histidine hydrochloride monohydrate (1.552 mg), L-methionine (0.373 mg), polysorbate 80 (0.1 mg), trehalose dihydrate (37.83 mg), and Sterile Water for Injection, USP, at pH of 5.8.COSENTYX Injection for Intravenous UseCOSENTYX solution is supplied as a sterile, preservative free, clear to opalescent, colorless to slightly yellowish solution in single-dose vials for intravenous infusion after dilution.Each COSENTYX vial contains 125 mg of secukinumab formulated in: L-histidine (5.67 mg), L-histidine hydrochloride monohydrate (13.3 mg), L-methionine (3.73 mg), polysorbate 80 (1 mg), trehalose dihydrate (426 mg), and Sterile Water for Injection, USP, at pH of 5.8.</section>

COSENTYX

secukinumab

1 ML secukinumab 150 MG/ML Prefilled Syringe

Cosentyx

1 ML secukinumab 150 MG/ML Prefilled Syringe [Cosentyx]

1 ML secukinumab 150 MG/ML Auto-Injector

1 ML secukinumab 150 MG/ML Auto-Injector [Cosentyx]

0.5 ML secukinumab 150 MG/ML Prefilled Syringe

0.5 ML secukinumab 150 MG/ML Prefilled Syringe [Cosentyx]

2 ML secukinumab 150 MG/ML Auto-Injector

2 ML secukinumab 150 MG/ML Auto-Injector [Cosentyx]

5 ML secukinumab 25 MG/ML Injection

5 ML secukinumab 25 MG/ML Injection [Cosentyx]

Chartwell Pennsylvania, L.P.

Actemra

Afinitor

Alecensa

Alunbrig

Ayvakit

Bafiertam

Bosulif

Bratovi

Brukinsa

Bynfezia

Cabometyx

Calquence

Cometriq

Copiktra

Cotellic

Dysport

Enbrel

Entyvio

Erivedge

Erleada

Farydak

Fotivda

Gavreto

Ibrance

Idhifa

Ilumya

Imbruvica

Inlyta

Inqovi

Inrebic

Iressa

Jakafi

Koselugo

Lonsurf

Lorbrena

Lyypraza

Mayzent

Mekinist

Mektovi

Nexavar

Nubeqa

Ocrevus

Odomzo

Piqray

Ponvory

Retevmo

Rutixan

Rozlytrek

Rubraca

Stelara

Stivarga

Sutent

Tabrecta

Tafinlar

Tagrisso

Talzenna

Tarceva

Targretin

Tasigna

Temodar

Tibsovo

Truseltiq

Tykerb

Tymlos

Venclexta

Vizimpro

Votrient

Vyndamax

Vyndaqel

Xalkori

Xolair

Xospata

Xpovio

Xtandi

Yonsa

Zelboraf

Zeposia

Zydelig

Zykadia

Cosentyx | Chartwell Pennsylvania, L.P. | limited distribution

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Which health plans does Chartwell Pennsylvania, L.P. have contracts with?

Does Chartwell Pennsylvania, L.P. work closely with Cosentyx and Novartis Pharmaceuticals Corporation?

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