Interleukin-17A Antagonist

Interleukin-17A Antagonists

Ankylosing Spondylitis

Psoriatic Arthritis

<section class="Section" data-sectioncode="34089-3"><a name="section-10"></a><h1>11     DESCRIPTION</h1>Secukinumab, a recombinant human monoclonal IgG1/κ antibody, is an interleukin-17A antagonist. It is expressed in a recombinant Chinese Hamster Ovary (CHO) cell line. Secukinumab has a molecular mass of approximately 151 kDa; both heavy chains of secukinumab contain oligosaccharide chains.COSENTYX InjectionCOSENTYX injection is a sterile, preservative-free, clear to slightly opalescent, colorless to slightly yellow solution for subcutaneous use. COSENTYX is supplied in a single-dose Sensoready pen with a 27-gauge fixed ½-inch needle, or a single-dose prefilled syringe with a 27-gauge fixed ½-inch needle. The removable cap of the COSENTYX Sensoready pen or prefilled syringe contains natural rubber latex.Each COSENTYX Sensoready pen or prefilled syringe contains 150 mg of secukinumab formulated in: L-histidine/histidine hydrochloride monohydrate (3.103 mg), L-methionine (0.746 mg), polysorbate 80 (0.2 mg), trehalose dihydrate (75.67 mg), and Sterile Water for Injection, USP, at pH of 5.8.Each COSENTYX 75 mg/0.5 mL prefilled syringe contains 75 mg of secukinumab formulated in: L-histidine/histidine hydrochloride monohydrate (1.552 mg), L-methionine (0.373 mg), polysorbate 80 (0.1 mg), trehalose dihydrate (37.83 mg), and Sterile Water for Injection, USP, at pH of 5.8. COSENTYX for InjectionCOSENTYX for injection is supplied as a sterile, preservative free, white to slightly yellow, lyophilized powder in single-dose vials for subcutaneous use after reconstitution. Each COSENTYX vial contains 150 mg of secukinumab formulated in L-histidine/histidine hydrochloride monohydrate (4.656 mg), polysorbate 80 (0.6 mg), and sucrose (92.43 mg). Following reconstitution with 1 mL Sterile Water for Injection, USP, the resulting pH is approximately 5.8.</section>

COSENTYX

0.5 ML secukinumab 150 MG/ML Prefilled Syringe

0.5 ML secukinumab 150 MG/ML Prefilled Syringe [Cosentyx]

1 ML secukinumab 150 MG/ML Auto-Injector

1 ML secukinumab 150 MG/ML Auto-Injector [Cosentyx]

1 ML secukinumab 150 MG/ML Prefilled Syringe

1 ML secukinumab 150 MG/ML Prefilled Syringe [Cosentyx]

Cosentyx

secukinumab

Proprium Specialty Pharmacy

Afinitor

Alunbrig

Bisulif

Cabometyx

Calquence

Cometriq

Daurismo

Dysport

Enbrel

Entyvio

Farydak

Fasenra

Ibrance

Inlyta

Iressa

Lorbrena

Lynparza

Mavenclad

Mayzent

Mekinist

Nerlynx

Nexavar

Ocrevus

Odomzo

Olumiant

Piqray

Promacta

Somavert

Somatuline

Stelara

Stivarga

Sutent

Synagis

Tafinlar

Tagrisso

Tasigna

Temodar

Tibsovo

Tykerb

Verzenio

Vizimpro

Votrient

Xalkori

Xolair

Zejula

Zeposia

Zykadia

Cosentyx | Proprium Specialty Pharmacy | limited distribution

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