Linzess (Linaclotide) Drug Interactions: 30 Moderate
Linzess (Linaclotide) Drug Interactions
Check all documented drug-to-drug interactions. Major, moderate, and minor interactions with descriptions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Linzess. Always confirm against the full prescribing information.
100 interactions
Acetazolamide
The risk or severity of dehydration can be increased when Acetazolamide is combined with Linaclotide.
Level 2 evidence
Amiloride
The risk or severity of dehydration can be increased when Amiloride is combined with Linaclotide.
Level 2 evidence
Bendroflumethiazide
The risk or severity of dehydration can be increased when Bendroflumethiazide is combined with Linaclotide.
Level 2 evidence
Bromotheophylline
The risk or severity of dehydration can be increased when Bromotheophylline is combined with Linaclotide.
Level 2 evidence
Bumetanide
The risk or severity of dehydration can be increased when Bumetanide is combined with Linaclotide.
Level 2 evidence
Chlorothiazide
The risk or severity of dehydration can be increased when Chlorothiazide is combined with Linaclotide.
Level 2 evidence
Chlorthalidone
The risk or severity of dehydration can be increased when Chlorthalidone is combined with Linaclotide.
Level 2 evidence
Conivaptan
The risk or severity of dehydration can be increased when Conivaptan is combined with Linaclotide.
Level 2 evidence
Diclofenamide
The risk or severity of dehydration can be increased when Diclofenamide is combined with Linaclotide.
Level 2 evidence
Drospirenone
The risk or severity of dehydration can be increased when Drospirenone is combined with Linaclotide.
Level 2 evidence
Eplerenone
The risk or severity of dehydration can be increased when Eplerenone is combined with Linaclotide.
Level 2 evidence
Etacrynic acid
The risk or severity of dehydration can be increased when Etacrynic acid is combined with Linaclotide.
Linzess (Linaclotide) has 190 documented drug interactions. Always review the full list with a pharmacist before co-prescribing.
Linzess (Linaclotide) has 0 major, 30 moderate, and 160 minor documented interactions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Linzess. Always confirm against the full prescribing information.