Nuclear Export Inhibitor

Nuclear Export Inhibitors

Multiple Myeloma

<section class="Section" data-sectioncode="34089-3"><a name="s48"></a><a name="section-8"></a><h1>11 DESCRIPTION</h1>Selinexor is a nuclear export inhibitor. Selinexor is (2Z)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1yl}-N'-(pyrazin-2-yl)prop-2-enehydrazide. It is a white to off-white powder and has the molecular formula C17H11F6N7O and a molecular mass of 443.31 g/mol. The molecular structure is shown below:<a name="f01"></a><img alt="Molecular Structure
" src="kar00-0014-01.jpg"/>XPOVIO tablets for oral dosing are supplied in four strengths, with each tablet containing 20 mg, 40 mg, 50 mg, or 60 mg of selinexor as the active ingredient. The inactive ingredients are colloidal silicon dioxide, croscarmellose sodium, magnesium stearate, microcrystalline cellulose, Opadry 200 clear, Opadry II blue, povidone K30, and sodium lauryl sulfate.</section>

XPOVIO

selinexor

selinexor 20 MG Oral Tablet

Xpovio

selinexor 20 MG Oral Tablet [Xpovio]

selinexor 60 MG Oral Tablet

selinexor 60 MG Oral Tablet [Xpovio]

selinexor 50 MG Oral Tablet

selinexor 50 MG Oral Tablet [Xpovio]

selinexor 40 MG Oral Tablet

selinexor 40 MG Oral Tablet [Xpovio]

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Report Adverse Event 

Prescribing Information

Medication Guide 

Submit MSL Request 

Pharmacy List 

Coverage Authorization Request 

Coverage Authorization Appeals 

Letter of Medical Necessity 

KaryForward Enrollment Form 

KaryForward Enrollment Form - Online

Patient Consent Form - Online 

Patient Consent Form - Spanish

Patient Consent Form - Chinese

Enroll in Patient Savings Program 

Dose Exchange Form 

Patient Assistance Program 

Bridge Program 

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Other HCP Resources: MM

Patient & Caregiver Brochure: MM

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Side Effects: MM

Taking Xpovio: MM

Patient Resources: MM

FAQs: MM

Instructions For Use: MM

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