Central Nervous System Depressant

Cataplexy

<section class="Section" data-sectioncode="34089-3"><a name="i4i_description_id_f8b62f4e-a47e-4a60-85f1-71e098162a28"></a><a name="section-11"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">Sodium oxybate, a CNS depressant, is the active ingredient in Xyrem. The chemical name for sodium oxybate is sodium 4-hydroxybutyrate. The molecular formula is C<span class="Sub">4</span>H<span class="Sub">7</span>NaO<span class="Sub">3</span>, and the molecular weight is 126.09 g/mole. The chemical structure is:</p><div class="Figure"><a name="id1683247962"></a><img alt="chemical structure" src="image-01.jpg"/></div><p>Sodium oxybate is a white to off-white, crystalline powder that is very soluble in aqueous solutions. Each mL of Xyrem contains 0.5 g of sodium oxybate (equivalent to 0.413 g/mL of oxybate) in USP Purified Water, neutralized to pH 7.5 with malic acid.</p></section>

Xyrem

oxybate

sodium oxybate 500 MG/ML Oral Solution

sodium oxybate 500 MG/ML Oral Solution [Xyrem]

sodium oxybate

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Report Adverse Event 

Prescribing Information 

Medication Guide 

Submit MSL Request 

Pharmacy List 

Reimbursement Information

Coverage Authorization Request 

Coverage Authorization Appeals

Enroll in Patient Savings Program 

JazzCares Patient Assistance Program 

Prescribing Xyrem 

About Xyrem: Adults 

About Xyrem: Pediatrics 

Getting Xyrem 

JazzCares For Xyrem 

Instructions For Use: Narcolepsy (Adults)

Instructions For Use: Narcolepsy (Pediatrics)

Doctor Discussion Guide 