| Angioedemas, Hereditary
Cinryze vs Takhzyro
Side-by-side clinical, coverage, and cost comparison for angioedemas, hereditary.Deep comparison between: Cinryze vs Takhzyro with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTakhzyro has a higher rate of injection site reactions vs Cinryze based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Takhzyro but not Cinryze, including UnitedHealthcare
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Category
Cinryze
Takhzyro
At A Glance
IV infusion
Every 3-4 days
C1 esterase inhibitor (serpin)
SC injection
Every 2-4 weeks
Plasma kallikrein inhibitor
Indications
- Angioedemas, Hereditary
- Angioedemas, Hereditary
Dosing
Angioedemas, Hereditary (adults and adolescents 12 years and above) 1,000 IU IV every 3 or 4 days at 1 mL/min (10 min); for inadequate responders, doses up to 2,000 IU (not exceeding 80 IU/kg) every 3 or 4 days may be considered.
Angioedemas, Hereditary (pediatric patients 6-11 years) 500 IU IV every 3 or 4 days at 1 mL/min (5 min); dose may be adjusted up to 1,000 IU every 3 or 4 days based on individual response.
Angioedemas, Hereditary (adults and pediatric >=12 years) 300 mg SC every 2 weeks; every 4 weeks may be considered if well-controlled (e.g., attack free) for more than 6 months.
Angioedemas, Hereditary (pediatric 6 to <12 years) 150 mg SC every 2 weeks; every 4 weeks may be considered if well-controlled (e.g., attack free) for more than 6 months.
Angioedemas, Hereditary (pediatric 2 to <6 years) 150 mg SC every 4 weeks.
Contraindications
- Life-threatening immediate hypersensitivity reactions, including anaphylaxis, to CINRYZE or any of its excipients
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Adverse Reactions
Most common (>=5%) Headache, nausea, rash, vomiting, fever
Serious Cerebrovascular accident
Postmarketing Local infusion site reactions (inflammation or hematoma at infusion site), hypersensitivity
Most common (>=10%) Injection site reactions, upper respiratory infections, headache, rash, dizziness, diarrhea, myalgia.
Less common Hypersensitivity, increased aspartate transaminase, increased alanine transaminase.
Pharmacology
C1 esterase inhibitor (serpin) that regulates complement and intrinsic coagulation (contact system) pathway activation; suppresses contact system activation by inactivating plasma kallikrein and factor XIIa, modulating vascular permeability by preventing bradykinin generation.
Plasma kallikrein inhibitor; lanadelumab-flyo is a fully human IgG1/kappa monoclonal antibody that binds and inhibits plasma kallikrein, reducing cleavage of high-molecular-weight kininogen and excess bradykinin generation that causes increased vascular permeability and angioedema attacks in HAE patients with C1-inhibitor deficiency or dysfunction.
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Most Common Insurance
Anthem BCBS
Cinryze
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (5/12) · Qty limit (9/12)
Takhzyro
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (9/12)
UnitedHealthcare
Cinryze
- Covered on 4 commercial plans
- PA (2/8) · Step Therapy (0/8) · Qty limit (0/8)
Takhzyro
- Covered on 4 commercial plans
- PA (4/8) · Step Therapy (0/8) · Qty limit (1/8)
Humana
Cinryze
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (2/3)
Takhzyro
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (2/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAccessia Health: Hereditary Angioedema - Private Insurance
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAccessia Health: Hereditary Angioedema - Private Insurance
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.