| Angioedemas, Hereditary
Takhzyro vs Orladeyo
Side-by-side clinical, coverage, and cost comparison for angioedemas, hereditary.Deep comparison between: Takhzyro vs Orladeyo with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsOrladeyo has a higher rate of injection site reactions vs Takhzyro based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Orladeyo but not Takhzyro, including UnitedHealthcare
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Category
Takhzyro
Orladeyo
At A Glance
SC injection
Every 2-4 weeks
Plasma kallikrein inhibitor
Oral
Once daily
Plasma kallikrein inhibitor
Indications
- Angioedemas, Hereditary
- Angioedemas, Hereditary
Dosing
Angioedemas, Hereditary (adults and pediatric >=12 years) 300 mg SC every 2 weeks; every 4 weeks may be considered if well-controlled (e.g., attack free) for more than 6 months.
Angioedemas, Hereditary (pediatric 6 to <12 years) 150 mg SC every 2 weeks; every 4 weeks may be considered if well-controlled (e.g., attack free) for more than 6 months.
Angioedemas, Hereditary (pediatric 2 to <6 years) 150 mg SC every 4 weeks.
Angioedemas, Hereditary (adults and pediatric patients >=12 years) 150 mg capsule orally once daily with food; reduce to 110 mg once daily with food for moderate or severe hepatic impairment (Child-Pugh Class B or C).
Angioedemas, Hereditary (pediatric patients 2 to <12 years) Weight-based oral pellets once daily with food: 72 mg (12 to <24 kg), 96 mg (24 to <32 kg), 108 mg (32 to <40 kg), or 132 mg (>=40 kg); avoid use in moderate or severe hepatic impairment.
Contraindications
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Adverse Reactions
Most common (>=10%) Injection site reactions, upper respiratory infections, headache, rash, dizziness, diarrhea, myalgia.
Less common Hypersensitivity, increased aspartate transaminase, increased alanine transaminase.
Most common (>=10%) Abdominal pain, vomiting, diarrhea, back pain, gastroesophageal reflux disease
Serious QTc interval prolongation (at supratherapeutic doses), transaminase elevations
Postmarketing Nausea
Pharmacology
Plasma kallikrein inhibitor; lanadelumab-flyo is a fully human IgG1/kappa monoclonal antibody that binds and inhibits plasma kallikrein, reducing cleavage of high-molecular-weight kininogen and excess bradykinin generation that causes increased vascular permeability and angioedema attacks in HAE patients with C1-inhibitor deficiency or dysfunction.
Plasma kallikrein inhibitor; berotralstat binds to and inhibits plasma kallikrein's proteolytic activity, thereby reducing bradykinin generation and preventing angioedema attacks in patients with HAE due to C1-inhibitor deficiency or dysfunction.
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Most Common Insurance
Anthem BCBS
Takhzyro
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (9/12)
Orladeyo
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (5/12) · Qty limit (9/12)
UnitedHealthcare
Takhzyro
- Covered on 4 commercial plans
- PA (4/8) · Step Therapy (0/8) · Qty limit (1/8)
Orladeyo
- Covered on 4 commercial plans
- PA (1/8) · Step Therapy (0/8) · Qty limit (1/8)
Humana
Takhzyro
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (2/3) · Qty limit (2/3)
Orladeyo
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (2/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAccessia Health: Hereditary Angioedema - Private Insurance
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAccessia Health: Hereditary Angioedema - Private Insurance
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.