| Chronic Kidney Diseases
Furoscix vs Xphozah
Side-by-side clinical, coverage, and cost comparison for chronic kidney diseases.Deep comparison between: Furoscix vs Xphozah 10 Mg with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsXphozah 10 Mg has a higher rate of injection site reactions vs Furoscix based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Xphozah 10 Mg but not Furoscix, including UnitedHealthcare
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Category
Furoscix
Xphozah 10 Mg
At A Glance
SC injection
Loop diuretic
Oral
Twice daily
NHE3 inhibitor
Indications
- Edema
- Chronic heart failure
- Chronic Kidney Diseases
- Nephrotic Syndrome
- Chronic Kidney Diseases
Dosing
Edema, Chronic heart failure, Chronic Kidney Diseases, Nephrotic Syndrome 30 mg subcutaneously over the first hour followed by 12.5 mg per hour for the subsequent 4 hours (total 80 mg) via On-body Infusor applied to the abdomen; not for chronic use, replace with oral diuretics as soon as practical.
Chronic Kidney Diseases 30 mg orally twice daily, taken just prior to the first and last meals of the day; monitor serum phosphorus and adjust dosage as needed for gastrointestinal tolerability.
Contraindications
- Anuria
- History of hypersensitivity to furosemide, any component of the FUROSCIX formulation, or medical adhesives
- Age under 6 years due to risk of diarrhea and serious dehydration
- Known or suspected mechanical gastrointestinal obstruction
Adverse Reactions
Serious fluid, electrolyte, and metabolic abnormalities, ototoxicity, anaphylactic or anaphylactoid reactions, aplastic anemia, toxic epidermal necrolysis, Stevens-Johnson syndrome, interstitial nephritis, necrotizing angiitis
Other reported pancreatitis, jaundice, nausea, vomiting, tinnitus, hearing loss, vertigo, dizziness, headache, thrombocytopenia, agranulocytosis, leukopenia, rash, erythema multiforme, orthostatic hypotension, injection site erythema and pain, muscle spasm, restlessness
Most common (>=5%) Diarrhea (43-53% of patients)
Postmarketing Pruritis, rash, urticaria
Pharmacology
Furosemide is a loop diuretic that primarily inhibits sodium and chloride reabsorption in the proximal and distal tubules and the loop of Henle, producing high-degree diuresis independent of carbonic anhydrase inhibition or aldosterone.
NHE3 inhibitor; tenapanor is a locally acting inhibitor of sodium/hydrogen exchanger 3 (NHE3), an antiporter on the apical surface of intestinal epithelium, whose inhibition reduces sodium absorption and decreases phosphate absorption by reducing paracellular phosphate permeability.
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Most Common Insurance
Anthem BCBS
Furoscix
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (5/12) · Qty limit (9/12)
Xphozah 10 Mg
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (9/12) · Qty limit (9/12)
UnitedHealthcare
Furoscix
- Covered on 4 commercial plans
- PA (5/8) · Step Therapy (4/8) · Qty limit (4/8)
Xphozah 10 Mg
- Covered on 4 commercial plans
- PA (2/8) · Step Therapy (0/8) · Qty limit (2/8)
Humana
Furoscix
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (2/3) · Qty limit (0/3)
Xphozah 10 Mg
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (1/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Furoscix.
No savings programs available for Xphozah 10 Mg.
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FuroscixView full Furoscix profile
Xphozah 10 MgView full Xphozah 10 Mg profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.