| Dry Eye Syndromes
Miebo vs Tyrvaya
Side-by-side clinical, coverage, and cost comparison for dry eye syndromes.Deep comparison between: Miebo vs Tyrvaya with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTyrvaya has a higher rate of injection site reactions vs Miebo based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Tyrvaya but not Miebo, including UnitedHealthcare
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Category
Miebo
Tyrvaya
At A Glance
Topical (ophthalmic)
4 times daily
Semifluorinated alkane
Nasal spray
Twice daily
Nicotinic acetylcholine receptor agonist
Indications
- Dry Eye Syndromes
- Dry Eye Syndromes
Dosing
Dry Eye Syndromes Instill one drop four times daily into each affected eye; remove contact lenses prior to and for at least 30 minutes after administration.
Dry Eye Syndromes One spray in each nostril twice daily, approximately 12 hours apart; prime with 7 actuations before initial use and re-prime with 1 actuation if not used for more than 5 days.
Contraindications
- History of hypersensitivity reaction to perfluorohexyloctane
—
Adverse Reactions
Most common (<4%) blurred vision, conjunctival redness
Premarketing studies hypersensitivity
Most common (>=5%) sneezing (82%), cough (16%), throat irritation (13%), instillation-site (nose) irritation (8%)
Pharmacology
Perfluorohexyloctane, a semifluorinated alkane, forms a monolayer at the air-liquid interface of the tear film that may reduce evaporation; the exact mechanism of action in dry eye disease is not known.
Nicotinic acetylcholine receptor agonist; varenicline binds heteromeric nACh receptor subtypes (alpha4beta2, alpha4alpha6beta2, alpha3beta4, alpha3alpha5beta4) and the alpha7 receptor, activating the trigeminal parasympathetic pathway to increase basal tear film production in dry eye disease.
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Most Common Insurance
Anthem BCBS
Miebo
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (11/12)
Tyrvaya
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
UnitedHealthcare
Miebo
- Covered on 4 commercial plans
- PA (4/8) · Step Therapy (0/8) · Qty limit (6/8)
Tyrvaya
- Covered on 4 commercial plans
- PA (4/8) · Step Therapy (4/8) · Qty limit (6/8)
Humana
Miebo
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Tyrvaya
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAssistance Fund: Thyroid Eye Disease (TED)
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
No savings programs available for Tyrvaya.
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TyrvayaView full Tyrvaya profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.