| HIV Infections
Pifeltro vs Stribild
Side-by-side clinical, coverage, and cost comparison for hiv infections.Deep comparison between: Pifeltro vs Stribild with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsStribild has a higher rate of injection site reactions vs Pifeltro based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Stribild but not Pifeltro, including UnitedHealthcare
Sign up to reveal the full AI analysis
Category
Pifeltro
Stribild
At A Glance
Oral
Once daily
NNRTI
Oral
Once daily
Integrase inhibitor + CYP3A inhibitor + nucleoside/nucleotide analog reverse transcriptase inhibitors
Indications
- HIV Infections
- HIV Infections
Dosing
HIV Infections One 100 mg tablet orally once daily with or without food in adults and pediatric patients weighing at least 35 kg.
HIV Infections (with rifabutin) One 100 mg tablet orally twice daily (approximately 12 hours apart) for the duration of rifabutin co-administration.
HIV Infections One tablet (elvitegravir 150 mg, cobicistat 150 mg, emtricitabine 200 mg, tenofovir disoproxil fumarate 300 mg) taken orally once daily with food in adults and pediatric patients 12 years of age and older with body weight at least 35 kg and creatinine clearance >=70 mL/min.
Contraindications
- Co-administration with carbamazepine, oxcarbazepine, phenobarbital, or phenytoin (anticonvulsants)
- Co-administration with enzalutamide (androgen receptor inhibitor)
- Co-administration with rifampin or rifapentine (antimycobacterials)
- Co-administration with mitotane (cytotoxic agent)
- Co-administration with St. John's wort (Hypericum perforatum)
- Coadministration with alfuzosin
- Coadministration with carbamazepine, phenobarbital, or phenytoin
- Coadministration with rifampin
- Coadministration with lurasidone or pimozide
- Coadministration with dihydroergotamine, ergotamine, or methylergonovine
- Coadministration with St. John's wort (Hypericum perforatum)
- Coadministration with lomitapide, lovastatin, or simvastatin
- Coadministration with sildenafil when used for pulmonary arterial hypertension
- Coadministration with triazolam or orally administered midazolam
Adverse Reactions
Most common (>=5%) Nausea, headache, fatigue, diarrhea, abdominal pain
Postmarketing Stevens-Johnson syndrome/toxic epidermal necrolysis, hepatitis, hepatic enzyme increased
Most common (>=5%) Diarrhea, nausea, headache, fatigue
Serious Severe acute exacerbations of hepatitis B in coinfected patients, new onset or worsening renal impairment, lactic acidosis/severe hepatomegaly with steatosis, bone loss and mineralization defects, immune reconstitution syndrome
Postmarketing Allergic reactions including angioedema, lactic acidosis, hypokalemia, hypophosphatemia, dyspnea, pancreatitis, increased amylase, abdominal pain, hepatic steatosis, hepatitis, increased liver enzymes, rash, rhabdomyolysis, osteomalacia, muscular weakness, myopathy, acute renal failure, renal failure, acute tubular necrosis, Fanconi syndrome, proximal renal tubulopathy, interstitial nephritis, nephrogenic diabetes insipidus, renal insufficiency, increased creatinine, proteinuria, polyuria, asthenia
Pharmacology
Doravirine is a pyridinone non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 that inhibits viral replication by non-competitive inhibition of HIV-1 reverse transcriptase and does not inhibit human cellular DNA polymerases alpha, beta, or mitochondrial DNA polymerase gamma.
STRIBILD is a fixed-dose combination of elvitegravir (an integrase strand transfer inhibitor), cobicistat (a CYP3A inhibitor that boosts elvitegravir levels), emtricitabine (a nucleoside reverse transcriptase inhibitor), and tenofovir disoproxil fumarate (a nucleotide reverse transcriptase inhibitor).
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Pifeltro
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (0/12) · Qty limit (11/12)
Stribild
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (11/12)
UnitedHealthcare
Pifeltro
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (2/8)
Stribild
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (3/8) · Qty limit (5/8)
Humana
Pifeltro
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (3/3)
Stribild
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
$0/fillfill
Delstrigo or Pifeltro Savings CouponCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
$0
Gilead Advancing Access Patient Assistance Program/Medication Assistance Program (PAP/MAP)Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Compare Other Drugs
Let us handle your prior authsJust enter your patient's info and we'll:
- Verify eligibility with the payer.
- Pull the right PA forms directly from the payer.
- Submit, track & send live updates to your dashboard.
Free to start · HIPAA compliant
Next Steps for Your Patient
PifeltroView full Pifeltro profile
StribildView full Stribild profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.