| Hospital acquired pneumonia
Fetroja vs Zerbaxa
Side-by-side clinical, coverage, and cost comparison for hospital acquired pneumonia.Deep comparison between: Fetroja vs Zerbaxa with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsZerbaxa has a higher rate of injection site reactions vs Fetroja based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Zerbaxa but not Fetroja, including UnitedHealthcare
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Category
Fetroja
Zerbaxa
At A Glance
IV infusion
Every 8 hours
Cephalosporin antibacterial
IV infusion
Every 8 hours
Cephalosporin/beta-lactamase inhibitor
Indications
- Complicated urinary tract infection
- Pyelonephritis
- Hospital acquired pneumonia
- Pneumonia, Ventilator-Associated
- Peritonitis
- Urinary tract infection
- Pyelonephritis
- Hospital acquired pneumonia
- VABP
Dosing
Complicated urinary tract infection, Pyelonephritis 2 grams IV infusion over 3 hours every 8 hours in adults with CLcr 60 to 119 mL/min; dose adjusted for CLcr <60 or >=120 mL/min; duration 7 to 14 days.
Hospital acquired pneumonia, Pneumonia, Ventilator-Associated 2 grams IV infusion over 3 hours every 8 hours in adults with CLcr 60 to 119 mL/min; dose adjusted for CLcr <60 or >=120 mL/min; duration 7 to 14 days.
Peritonitis 1.5 g IV every 8 hours over 1 hour for 4 to 14 days, used in conjunction with metronidazole 500 mg IV every 8 hours; pediatric patients: 30 mg/kg up to 1.5 g every 8 hours for 5 to 14 days.
Urinary tract infection, Pyelonephritis 1.5 g IV every 8 hours over 1 hour for 7 days; pediatric patients: 30 mg/kg up to 1.5 g every 8 hours for 7 to 14 days.
Hospital acquired pneumonia, VABP 3 g IV every 8 hours over 1 hour for 8 to 14 days in adult patients 18 years and older.
Contraindications
- Known history of severe hypersensitivity to cefiderocol, other beta-lactam antibacterial drugs, or any other component of FETROJA
- Known serious hypersensitivity to components of ZERBAXA (ceftolozane and tazobactam), piperacillin/tazobactam, or other members of the beta-lactam class
Adverse Reactions
Most common (>=2%) Diarrhea, elevations in liver tests, hypokalemia, infusion site reactions, constipation, rash, candidiasis, headache, nausea, vomiting, hypomagnesemia, atrial fibrillation
Serious Increase in all-cause mortality in carbapenem-resistant gram-negative bacterial infections, hypersensitivity reactions, Clostridioides difficile-associated diarrhea, seizures and other central nervous system adverse reactions
Postmarketing Neutropenia, chromaturia
Most common (>=5%) Nausea, diarrhea, headache, pyrexia
Serious Hypersensitivity reactions, Clostridioides difficile-associated diarrhea, intracranial hemorrhage, renal impairment/renal failure, hepatic transaminase increased
Pharmacology
Cefiderocol is a cephalosporin antibacterial that functions as a siderophore, using the bacterial iron uptake mechanism to traverse the outer cell membrane and exert bactericidal activity by inhibiting cell wall biosynthesis through binding to penicillin-binding proteins (PBPs).
Ceftolozane is a cephalosporin antibacterial that inhibits bacterial cell wall biosynthesis by binding to penicillin-binding proteins (PBPs); tazobactam is an irreversible beta-lactamase inhibitor that extends ceftolozane activity against beta-lactamase-producing organisms.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Fetroja
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (0/12) · Qty limit (0/12)
Zerbaxa
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (6/12) · Qty limit (0/12)
UnitedHealthcare
Fetroja
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Zerbaxa
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Fetroja
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (0/3) · Qty limit (2/3)
Zerbaxa
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Fetroja.
No savings programs available for Zerbaxa.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.