| Hospital acquired pneumonia
Zerbaxa vs Xacduro
Side-by-side clinical, coverage, and cost comparison for hospital acquired pneumonia.Deep comparison between: Zerbaxa vs Xacduro with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsXacduro has a higher rate of injection site reactions vs Zerbaxa based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Xacduro but not Zerbaxa, including UnitedHealthcare
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Category
Zerbaxa
Xacduro
At A Glance
IV infusion
Every 8 hours
Cephalosporin/beta-lactamase inhibitor
IV infusion
Every 6 hours
Beta-lactam/beta-lactamase inhibitor
Indications
- Peritonitis
- Urinary tract infection
- Pyelonephritis
- Hospital acquired pneumonia
- VABP
- Hospital acquired pneumonia
- Pneumonia, Ventilator-Associated
Dosing
Peritonitis 1.5 g IV every 8 hours over 1 hour for 4 to 14 days, used in conjunction with metronidazole 500 mg IV every 8 hours; pediatric patients: 30 mg/kg up to 1.5 g every 8 hours for 5 to 14 days.
Urinary tract infection, Pyelonephritis 1.5 g IV every 8 hours over 1 hour for 7 days; pediatric patients: 30 mg/kg up to 1.5 g every 8 hours for 7 to 14 days.
Hospital acquired pneumonia, VABP 3 g IV every 8 hours over 1 hour for 8 to 14 days in adult patients 18 years and older.
Hospital acquired pneumonia, Pneumonia, Ventilator-Associated 1 g sulbactam and 1 g durlobactam every 6 hours by IV infusion over 3 hours in adults with CLcr 45-129 mL/min; adjust dose for other renal function levels; treat for 7 to 14 days.
Contraindications
- Known serious hypersensitivity to components of ZERBAXA (ceftolozane and tazobactam), piperacillin/tazobactam, or other members of the beta-lactam class
- Known severe hypersensitivity to sulbactam, durlobactam, or other beta-lactam antibacterial drugs
Adverse Reactions
Most common (>=5%) Nausea, diarrhea, headache, pyrexia
Serious Hypersensitivity reactions, Clostridioides difficile-associated diarrhea, intracranial hemorrhage, renal impairment/renal failure, hepatic transaminase increased
Most common (>10%) Liver test abnormalities, diarrhea, anemia, hypokalemia
Serious Hypersensitivity reactions, Clostridioides difficile-associated diarrhea
Pharmacology
Ceftolozane is a cephalosporin antibacterial that inhibits bacterial cell wall biosynthesis by binding to penicillin-binding proteins (PBPs); tazobactam is an irreversible beta-lactamase inhibitor that extends ceftolozane activity against beta-lactamase-producing organisms.
Sulbactam is a beta-lactam antibacterial and beta-lactamase inhibitor that exerts bactericidal activity by inhibiting Acinetobacter baumannii-calcoaceticus complex PBP1 and PBP3; durlobactam is a diazabicyclooctane beta-lactamase inhibitor that protects sulbactam from degradation by serine beta-lactamases without intrinsic antibacterial activity against ABC isolates.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Zerbaxa
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (6/12) · Qty limit (0/12)
Xacduro
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Zerbaxa
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Xacduro
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Zerbaxa
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Xacduro
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Zerbaxa.
No savings programs available for Xacduro.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.