| Human immunodeficiency virus I infection
Complera vs Triumeq
Side-by-side clinical, coverage, and cost comparison for human immunodeficiency virus i infection.Deep comparison between: Complera vs Triumeq with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTriumeq has a higher rate of injection site reactions vs Complera based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Triumeq but not Complera, including UnitedHealthcare
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Category
Complera
Triumeq
At A Glance
Oral
Once daily
NRTI/NNRTI fixed-dose combination
Oral
Once daily
INSTI + dual NRTI antiretroviral combination
Indications
- Human immunodeficiency virus I infection
- Human immunodeficiency virus I infection
Dosing
Human immunodeficiency virus I infection One tablet orally once daily with food for adults and pediatric patients weighing at least 35 kg; not recommended in patients with estimated creatinine clearance below 50 mL/min.
Pregnancy One tablet once daily may be continued in virologically suppressed patients (HIV-1 RNA less than 50 copies/mL); monitor viral load closely due to lower rilpivirine exposures during pregnancy.
Rifabutin coadministration Add one additional 25 mg rilpivirine (Edurant) tablet once daily with a meal for the duration of rifabutin coadministration.
Human immunodeficiency virus I infection Adults: One tablet of TRIUMEQ (600 mg abacavir, 50 mg dolutegravir, 300 mg lamivudine) once daily orally with or without food. Pediatric patients >=25 kg: One tablet TRIUMEQ once daily. Pediatric patients 6 to <10 kg: 3 tablets TRIUMEQ PD (180 mg abacavir, 15 mg dolutegravir, 90 mg lamivudine) once daily dispersed in water. Pediatric patients 10 to <14 kg: 4 tablets TRIUMEQ PD (240 mg abacavir, 20 mg dolutegravir, 120 mg lamivudine) once daily dispersed in water. Pediatric patients 14 to <20 kg: 5 tablets TRIUMEQ PD (300 mg abacavir, 25 mg dolutegravir, 150 mg lamivudine) once daily dispersed in water. Pediatric patients 20 to <25 kg: 6 tablets TRIUMEQ PD (360 mg abacavir, 30 mg dolutegravir, 180 mg lamivudine) once daily dispersed in water. Screen for HLA-B*5701 allele and test for HBV infection before initiating. Adjust dolutegravir to 50 mg twice daily when coadministered with efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, carbamazepine, or rifampin.
Contraindications
- Coadministration with carbamazepine, oxcarbazepine, phenobarbital, or phenytoin
- Coadministration with rifampin or rifapentine
- Coadministration with dexamethasone (systemic, more than a single dose)
- Coadministration with St John's wort (Hypericum perforatum)
- Coadministration with proton pump inhibitors (e.g., dexlansoprazole, esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole)
- Presence of HLA-B*5701 allele
- Prior hypersensitivity reaction to abacavir, dolutegravir, or lamivudine
- Concomitant use with dofetilide
- Moderate or severe hepatic impairment
Adverse Reactions
Most common (>=2%) Depressive disorders, headache, insomnia, abnormal dreams, dizziness, nausea, rash
Serious Severe acute exacerbations of hepatitis B, skin and hypersensitivity reactions, hepatotoxicity, depressive disorders, new onset or worsening renal impairment, bone loss and mineralization defects, lactic acidosis/severe hepatomegaly with steatosis, immune reconstitution syndrome
Postmarketing Weight gain, severe skin and hypersensitivity reactions including DRESS, nephrotic syndrome, allergic reaction including angioedema, lactic acidosis, pancreatitis, rhabdomyolysis, osteomalacia, acute renal failure, Fanconi syndrome
Most common (>=2%) Insomnia, headache, fatigue, nausea, diarrhea
Serious Serious and sometimes fatal hypersensitivity reaction with abacavir, exacerbations of hepatitis B, hepatotoxicity, lactic acidosis and severe hepatomegaly with steatosis, immune reconstitution syndrome, myocardial infarction
Postmarketing Aplastic anemia, anemia, lymphadenopathy, splenomegaly, stomatitis, pancreatitis, acute liver failure, sensitization reactions including anaphylaxis and urticaria, weight increase, hyperlactemia, CPK elevation, muscle weakness, myalgia, rhabdomyolysis, peripheral neuropathy, seizures, anxiety, alopecia, erythema multiforme, suspected Stevens-Johnson syndrome, toxic epidermal necrolysis
Pharmacology
COMPLERA is a fixed-dose combination antiretroviral containing emtricitabine (nucleoside reverse transcriptase inhibitor), rilpivirine (non-nucleoside reverse transcriptase inhibitor), and tenofovir disoproxil fumarate (nucleotide reverse transcriptase inhibitor); each component inhibits HIV-1 reverse transcriptase through distinct mechanisms to suppress viral replication.
TRIUMEQ and TRIUMEQ PD are fixed-dose combinations of three HIV-1 antiretroviral agents: dolutegravir (an integrase strand transfer inhibitor that blocks HIV replication by binding to the integrase active site and inhibiting the strand transfer step), abacavir (a nucleoside analogue that is converted to carbovir triphosphate which inhibits HIV-1 reverse transcriptase by competing with dGTP and incorporating into viral DNA), and lamivudine (a nucleoside analogue phosphorylated to lamivudine triphosphate which inhibits reverse transcriptase via DNA chain termination).
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Most Common Insurance
Anthem BCBS
Complera
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (9/12)
Triumeq
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (11/12)
UnitedHealthcare
Complera
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (8/8)
Triumeq
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (8/8)
Humana
Complera
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (3/3)
Triumeq
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
$0
Gilead Advancing Access Patient Assistance Program/Medication Assistance Program (PAP/MAP)Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableGood Days: HIV, AIDS Treatment & Prevention
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.