| Human immunodeficiency virus I infection
Evotaz vs Triumeq
Side-by-side clinical, coverage, and cost comparison for human immunodeficiency virus i infection.Deep comparison between: Evotaz vs Triumeq with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTriumeq has a higher rate of injection site reactions vs Evotaz based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Triumeq but not Evotaz, including UnitedHealthcare
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Category
Evotaz
Triumeq
At A Glance
Oral
Once daily
HIV-1 protease inhibitor with CYP3A inhibitor
Oral
Once daily
INSTI + dual NRTI antiretroviral combination
Indications
- Human immunodeficiency virus I infection
- Human immunodeficiency virus I infection
Dosing
Human immunodeficiency virus I infection One tablet (atazanavir 300 mg/cobicistat 150 mg) orally once daily with food.
Human immunodeficiency virus I infection Adults: One tablet of TRIUMEQ (600 mg abacavir, 50 mg dolutegravir, 300 mg lamivudine) once daily orally with or without food. Pediatric patients >=25 kg: One tablet TRIUMEQ once daily. Pediatric patients 6 to <10 kg: 3 tablets TRIUMEQ PD (180 mg abacavir, 15 mg dolutegravir, 90 mg lamivudine) once daily dispersed in water. Pediatric patients 10 to <14 kg: 4 tablets TRIUMEQ PD (240 mg abacavir, 20 mg dolutegravir, 120 mg lamivudine) once daily dispersed in water. Pediatric patients 14 to <20 kg: 5 tablets TRIUMEQ PD (300 mg abacavir, 25 mg dolutegravir, 150 mg lamivudine) once daily dispersed in water. Pediatric patients 20 to <25 kg: 6 tablets TRIUMEQ PD (360 mg abacavir, 30 mg dolutegravir, 180 mg lamivudine) once daily dispersed in water. Screen for HLA-B*5701 allele and test for HBV infection before initiating. Adjust dolutegravir to 50 mg twice daily when coadministered with efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, carbamazepine, or rifampin.
Contraindications
- Clinically significant hypersensitivity (e.g., Stevens-Johnson syndrome, erythema multiforme, toxic skin eruptions) to any component
- Coadministration with strong CYP3A4 inducers
- Coadministration with drugs highly dependent on CYP3A or UGT1A1 for clearance with narrow therapeutic indices
- Coadministration with alfuzosin
- Coadministration with ranolazine
- Coadministration with dronedarone
- Coadministration with carbamazepine, phenobarbital, phenytoin
- Coadministration with colchicine in patients with hepatic or renal impairment
- Coadministration with rifampin
- Coadministration with apalutamide, encorafenib, irinotecan, ivosidenib
- Coadministration with lurasidone, pimozide
- Coadministration with dihydroergotamine, ergotamine, methylergonovine
- Coadministration with elbasvir/grazoprevir, glecaprevir/pibrentasvir
- Coadministration with St. John's wort (Hypericum perforatum)
- Coadministration with drospirenone/ethinyl estradiol
- Coadministration with lomitapide, lovastatin, simvastatin
- Coadministration with nevirapine
- Coadministration with sildenafil when used for pulmonary arterial hypertension
- Coadministration with indinavir
- Coadministration with triazolam, orally administered midazolam
- Presence of HLA-B*5701 allele
- Prior hypersensitivity reaction to abacavir, dolutegravir, or lamivudine
- Concomitant use with dofetilide
- Moderate or severe hepatic impairment
Adverse Reactions
Most common (>=5%) Jaundice, rash
Serious Cardiac conduction abnormalities, rash, effects on serum creatinine, new onset or worsening renal impairment, chronic kidney disease, nephrolithiasis, cholelithiasis, hepatotoxicity, hyperbilirubinemia
Most common (>=2%) Insomnia, headache, fatigue, nausea, diarrhea
Serious Serious and sometimes fatal hypersensitivity reaction with abacavir, exacerbations of hepatitis B, hepatotoxicity, lactic acidosis and severe hepatomegaly with steatosis, immune reconstitution syndrome, myocardial infarction
Postmarketing Aplastic anemia, anemia, lymphadenopathy, splenomegaly, stomatitis, pancreatitis, acute liver failure, sensitization reactions including anaphylaxis and urticaria, weight increase, hyperlactemia, CPK elevation, muscle weakness, myalgia, rhabdomyolysis, peripheral neuropathy, seizures, anxiety, alopecia, erythema multiforme, suspected Stevens-Johnson syndrome, toxic epidermal necrolysis
Pharmacology
EVOTAZ is a fixed-dose combination of atazanavir, an HIV-1 protease inhibitor that prevents viral Gag and Gag-Pol polyprotein processing, and cobicistat, a CYP3A inhibitor that increases atazanavir systemic exposure.
TRIUMEQ and TRIUMEQ PD are fixed-dose combinations of three HIV-1 antiretroviral agents: dolutegravir (an integrase strand transfer inhibitor that blocks HIV replication by binding to the integrase active site and inhibiting the strand transfer step), abacavir (a nucleoside analogue that is converted to carbovir triphosphate which inhibits HIV-1 reverse transcriptase by competing with dGTP and incorporating into viral DNA), and lamivudine (a nucleoside analogue phosphorylated to lamivudine triphosphate which inhibits reverse transcriptase via DNA chain termination).
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Evotaz
- Covered on 5 commercial plans
- PA (4/12) · Step Therapy (0/12) · Qty limit (11/12)
Triumeq
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (11/12)
UnitedHealthcare
Evotaz
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (4/8)
Triumeq
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (8/8)
Humana
Evotaz
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (3/3)
Triumeq
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableGood Days: HIV, AIDS Treatment & Prevention
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableGood Days: HIV, AIDS Treatment & Prevention
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.