| Hypogonadotropic hypogonadism
AndroGel vs Tlando
Side-by-side clinical, coverage, and cost comparison for hypogonadotropic hypogonadism.Deep comparison between: Androgel vs Tlando with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTlando has a higher rate of injection site reactions vs Androgel based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Tlando but not Androgel, including UnitedHealthcare
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Category
Androgel
Tlando
At A Glance
Topical
Daily
Androgen
Oral
Twice daily
Androgen
Indications
- Primary hypogonadism
- Hypogonadotropic hypogonadism
- Primary hypogonadism
- Hypogonadotropic hypogonadism
Dosing
Primary hypogonadism, Hypogonadotropic hypogonadism Starting dose 40.5 mg testosterone (2 pump actuations or one 40.5 mg packet) applied once daily to upper arms and shoulders; titrate between 20.25 mg and 81 mg based on pre-dose morning serum testosterone at days 14 and 28 after starting or adjusting dose.
Primary hypogonadism, Hypogonadotropic hypogonadism 225 mg (two 112.5 mg capsules) orally twice daily with food, once in the morning and once in the evening; monitor serum testosterone 8-9 hours after morning dose at 3-4 weeks and periodically thereafter.
Contraindications
- Carcinoma of the breast
- Known or suspected carcinoma of the prostate
- Pregnancy (can cause virilization of the female fetus)
- Carcinoma of the breast or known or suspected carcinoma of the prostate
- Pregnancy (testosterone can cause virilization of the female fetus)
- Known hypersensitivity to testosterone undecanoate or any of TLANDO's ingredients
Adverse Reactions
Most common (>=5%) PSA increased
Serious Nonfatal arrhythmias warranting intervention, atrial fibrillation, acute kidney injury, bone fracture
Postmarketing Myocardial infarction, stroke, polycythemia, prostate cancer, venous thromboembolism, sleep apnea, priapism, gynecomastia
Most common (>=2%) increased blood prolactin, hypertension, increased hematocrit, upper respiratory tract infection, weight increased, headache, musculoskeletal pain
Serious polycythemia, venous thromboembolism, worsening of benign prostatic hyperplasia and potential risk of prostate cancer, blood pressure increases, hepatic adverse effects, edema, sleep apnea, gynecomastia, lipid changes, hypercalcemia
Postmarketing myocardial infarction, stroke, venous thromboembolism
Pharmacology
Endogenous androgen replacement; testosterone and dihydrotestosterone (DHT) are responsible for normal growth and development of male sex organs and maintenance of secondary sex characteristics, with male hypogonadism resulting from insufficient testosterone secretion due to gonadal defects (primary) or hypothalamic/pituitary failure (hypogonadotropic).
Androgen; testosterone undecanoate is a lipophilic ester of testosterone that, after oral absorption primarily via the lymphatic system (bypassing first-pass hepatic metabolism), is converted to testosterone, which is responsible for normal growth and development of male sex organs and maintenance of secondary sex characteristics.
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Most Common Insurance
Anthem BCBS
Androgel
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (0/12)
Tlando
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (9/12) · Qty limit (10/12)
UnitedHealthcare
Androgel
- Covered on 4 commercial plans
- PA (5/8) · Step Therapy (0/8) · Qty limit (0/8)
Tlando
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Androgel
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Tlando
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Androgel.
No savings programs available for Tlando.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.