| Infantile Severe Myoclonic Epilepsy
Diacomit vs Epidiolex
Side-by-side clinical, coverage, and cost comparison for infantile severe myoclonic epilepsy.Deep comparison between: Diacomit vs Epidiolex with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsEpidiolex has a higher rate of injection site reactions vs Diacomit based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Epidiolex but not Diacomit, including UnitedHealthcare
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Category
Diacomit
Epidiolex
At A Glance
Oral
Twice or three times daily
Anticonvulsant
Oral
Twice daily
Cannabinoid antiepileptic
Indications
- Infantile Severe Myoclonic Epilepsy
- Lennox-Gastaut syndrome
- Infantile Severe Myoclonic Epilepsy
- Tuberous Sclerosis
Dosing
Infantile Severe Myoclonic Epilepsy 50 mg/kg/day orally in 2 or 3 equally divided doses (25 mg/kg twice daily or 16.67 mg/kg three times daily) for patients 6 months of age and older weighing 7 kg or more; maximum 3,000 mg/day.
Lennox-Gastaut syndrome, Infantile Severe Myoclonic Epilepsy Starting 2.5 mg/kg orally twice daily (5 mg/kg/day); increase after 1 week to maintenance 5 mg/kg twice daily (10 mg/kg/day); may increase up to maximum 10 mg/kg twice daily (20 mg/kg/day) in weekly increments based on response and tolerability.
Tuberous Sclerosis Starting 2.5 mg/kg orally twice daily (5 mg/kg/day); increase weekly by 2.5 mg/kg twice daily (5 mg/kg/day) as tolerated to recommended maintenance 12.5 mg/kg twice daily (25 mg/kg/day).
Contraindications
—
- History of hypersensitivity to cannabidiol or any excipient in EPIDIOLEX
Adverse Reactions
Most common (>=10%) Somnolence, decreased appetite, agitation, ataxia, weight decreased, hypotonia, nausea, tremor, dysarthria, insomnia
Serious Somnolence, decreased appetite and decreased weight, neutropenia and thrombocytopenia, withdrawal symptoms, suicidal behavior and ideation
Most common (>=10%) Somnolence, decreased appetite, diarrhea, transaminase elevations, fatigue, malaise, asthenia, rash, insomnia, pyrexia, vomiting
Serious Hepatic injury, somnolence and sedation, suicidal behavior and ideation, hypersensitivity reactions
Pharmacology
DIACOMIT is an anticonvulsant whose exact mechanism is unknown; possible mechanisms include direct modulation of the GABA-A receptor and indirect inhibition of cytochrome P450 activity that increases plasma concentrations of clobazam and its active metabolite norclobazam.
Cannabidiol is a phytocannabinoid antiepileptic; its precise mechanisms of anticonvulsant action in humans are unknown and do not appear to involve interaction with cannabinoid receptors.
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Most Common Insurance
Anthem BCBS
Diacomit
- Covered on 5 commercial plans
- PA (12/12) · Step Therapy (11/12) · Qty limit (11/12)
Epidiolex
- Covered on 5 commercial plans
- PA (12/12) · Step Therapy (12/12) · Qty limit (0/12)
UnitedHealthcare
Diacomit
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (6/8) · Qty limit (4/8)
Epidiolex
- Covered on 4 commercial plans
- PA (7/8) · Step Therapy (6/8) · Qty limit (0/8)
Humana
Diacomit
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (1/3) · Qty limit (3/3)
Epidiolex
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableDiacomit Bridge Program
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAssistance Fund: Epilepsy (Seizures): Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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DiacomitView full Diacomit profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.