| Lennox-Gastaut Syndrome
Onfi vs Sympazan
Side-by-side clinical, coverage, and cost comparison for lennox-gastaut syndrome.Deep comparison between: Onfi vs Sympazan with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsSympazan has a higher rate of injection site reactions vs Onfi based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Sympazan but not Onfi, including UnitedHealthcare
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Category
Onfi
Sympazan
At A Glance
Oral
Once or twice daily
Benzodiazepine
Oral film
Twice daily
Benzodiazepine
Indications
- Lennox-Gastaut syndrome
- Lennox-Gastaut syndrome
Dosing
Lennox-Gastaut syndrome Weight-based oral dosing: <=30 kg start at 5 mg/day titrated to 20 mg/day; >30 kg start at 10 mg/day titrated to 40 mg/day; doses >5 mg/day given in two divided doses twice daily; escalate no faster than weekly.
Lennox-Gastaut syndrome Weight <=30 kg: initiate at 5 mg/day, titrate up to 20 mg/day; weight >30 kg: initiate at 10 mg/day, titrate up to 40 mg/day; doses above 5 mg/day given in two divided doses twice daily; do not escalate more rapidly than weekly.
Contraindications
- History of hypersensitivity to clobazam or any of its ingredients
- History of hypersensitivity to clobazam or any of its ingredients, including serious dermatological reactions
Adverse Reactions
Most common (>=5%) Somnolence or sedation, pyrexia, upper respiratory tract infection, lethargy, drooling, aggression, vomiting, irritability, insomnia, fatigue, cough
Serious Serious dermatological reactions, DRESS/multiorgan hypersensitivity, respiratory depression with opioids, dependence and withdrawal reactions, suicidal behavior and ideation, neonatal sedation and withdrawal syndrome
Postmarketing Anemia, eosinophilia, leukopenia, thrombocytopenia, diplopia, blurred vision, abdominal distention, hypothermia, elevated hepatic enzymes, muscle spasms, agitation, anxiety, confusional state, depression, hallucination, urinary retention, respiratory depression, rash, urticaria, angioedema
Most common (>=5%) Somnolence or sedation, pyrexia, upper respiratory tract infection, lethargy, aggression, drooling, irritability, insomnia, ataxia, vomiting, constipation, cough, fatigue, decreased appetite, increased appetite
Serious Respiratory depression (with opioids), abuse and addiction, dependence and withdrawal reactions, serious dermatological reactions, drug reaction with eosinophilia and systemic symptoms (DRESS), suicidal behavior and ideation, neonatal sedation and withdrawal syndrome
Postmarketing Anemia, eosinophilia, leukopenia, thrombocytopenia, diplopia, blurred vision, abdominal distention, hypothermia, hepatic enzyme increased, muscle spasms, agitation, anxiety, depression, delirium, hallucination, urinary retention, aspiration, respiratory depression, rash, urticaria, angioedema
Pharmacology
Clobazam is a 1,5-benzodiazepine whose exact mechanism is not fully understood but is thought to involve potentiation of GABAergic neurotransmission through binding at the benzodiazepine site of the GABA-A receptor.
Clobazam is a 1,5-benzodiazepine whose mechanism is thought to involve potentiation of GABAergic neurotransmission through binding at the benzodiazepine site of the GABA-A receptor; it is extensively metabolized to N-desmethylclobazam, an active metabolite with approximately 1/5 the activity of the parent compound.
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Most Common Insurance
Anthem BCBS
Onfi
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (1/12) · Qty limit (9/12)
Sympazan
- Covered on 5 commercial plans
- PA (8/12) · Step Therapy (3/12) · Qty limit (11/12)
UnitedHealthcare
Onfi
- Covered on 4 commercial plans
- PA (5/8) · Step Therapy (4/8) · Qty limit (1/8)
Sympazan
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (4/8) · Qty limit (2/8)
Humana
Onfi
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (1/3)
Sympazan
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
$10/fillfill
Onfi Copay Savings ProgramCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
No savings programs available for Sympazan.
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SympazanView full Sympazan profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.