| Lennox-Gastaut Syndrome

Sympazan vs Epidiolex

Side-by-side clinical, coverage, and cost comparison for lennox-gastaut syndrome.

Deep comparison between: Sympazan vs Epidiolex with Prescriber.AI

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Safety signalsEpidiolex has a higher rate of injection site reactions vs Sympazan based on FDA-approved prescribing information

Coverage gaps3 major payers require step therapy for Epidiolex but not Sympazan, including UnitedHealthcare

Category

Sympazan

Epidiolex

At A Glance

RouteOral film

FrequencyTwice daily

ClassBenzodiazepine

RouteOral

FrequencyTwice daily

ClassCannabinoid antiepileptic

Indications

Lennox-Gastaut syndrome

Lennox-Gastaut syndrome
Infantile Severe Myoclonic Epilepsy
Tuberous Sclerosis

Dosing

Lennox-Gastaut syndrome Weight <=30 kg: initiate at 5 mg/day, titrate up to 20 mg/day; weight >30 kg: initiate at 10 mg/day, titrate up to 40 mg/day; doses above 5 mg/day given in two divided doses twice daily; do not escalate more rapidly than weekly.

Lennox-Gastaut syndrome, Infantile Severe Myoclonic Epilepsy Starting 2.5 mg/kg orally twice daily (5 mg/kg/day); increase after 1 week to maintenance 5 mg/kg twice daily (10 mg/kg/day); may increase up to maximum 10 mg/kg twice daily (20 mg/kg/day) in weekly increments based on response and tolerability.

Tuberous Sclerosis Starting 2.5 mg/kg orally twice daily (5 mg/kg/day); increase weekly by 2.5 mg/kg twice daily (5 mg/kg/day) as tolerated to recommended maintenance 12.5 mg/kg twice daily (25 mg/kg/day).

Contraindications

History of hypersensitivity to clobazam or any of its ingredients, including serious dermatological reactions

History of hypersensitivity to cannabidiol or any excipient in EPIDIOLEX

Drug Interactions

1306View drug interactions

1213View drug interactions

Adverse Reactions

Most common (>=5%) Somnolence or sedation, pyrexia, upper respiratory tract infection, lethargy, aggression, drooling, irritability, insomnia, ataxia, vomiting, constipation, cough, fatigue, decreased appetite, increased appetite

Serious Respiratory depression (with opioids), abuse and addiction, dependence and withdrawal reactions, serious dermatological reactions, drug reaction with eosinophilia and systemic symptoms (DRESS), suicidal behavior and ideation, neonatal sedation and withdrawal syndrome

Postmarketing Anemia, eosinophilia, leukopenia, thrombocytopenia, diplopia, blurred vision, abdominal distention, hypothermia, hepatic enzyme increased, muscle spasms, agitation, anxiety, depression, delirium, hallucination, urinary retention, aspiration, respiratory depression, rash, urticaria, angioedema

Most common (>=10%) Somnolence, decreased appetite, diarrhea, transaminase elevations, fatigue, malaise, asthenia, rash, insomnia, pyrexia, vomiting

Serious Hepatic injury, somnolence and sedation, suicidal behavior and ideation, hypersensitivity reactions

Pharmacology

Clobazam is a 1,5-benzodiazepine whose mechanism is thought to involve potentiation of GABAergic neurotransmission through binding at the benzodiazepine site of the GABA-A receptor; it is extensively metabolized to N-desmethylclobazam, an active metabolite with approximately 1/5 the activity of the parent compound.

Cannabidiol is a phytocannabinoid antiepileptic; its precise mechanisms of anticonvulsant action in humans are unknown and do not appear to involve interaction with cannabinoid receptors.

View Full FDA Information

View full FDA information

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Most Common Insurance

Anthem BCBS

Sympazan