| Menorrhagia
Mirena vs Natazia
Side-by-side clinical, coverage, and cost comparison for menorrhagia.Deep comparison between: Mirena vs Natazia with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsNatazia has a higher rate of injection site reactions vs Mirena based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Natazia but not Mirena, including UnitedHealthcare
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Category
Mirena
Natazia
At A Glance
Intrauterine (IUS)
Continuous release
Progestin IUS
Oral
Daily
Combined oral contraceptive
Indications
- Menorrhagia
- Menorrhagia
Dosing
Contraception Insert 52 mg LNG intrauterine system by a trained healthcare provider using aseptic technique; releases approximately 21 mcg/day initially, declining to approximately 7 mcg/day by year 8; replace by the end of the eighth year.
Menorrhagia Insert 52 mg LNG intrauterine system by a trained healthcare provider using aseptic technique; replace by the end of the fifth year if continued treatment is needed.
Menorrhagia One tablet daily by mouth at the same time every day, taken in the order directed on the blister pack for a 28-day sequential regimen; do not skip or delay intake by more than 12 hours.
Contraindications
- Pregnancy or suspected pregnancy
- Intended use as post-coital (emergency) contraception
- Congenital or acquired uterine anomaly, including fibroids, distorting the uterine cavity
- Acute pelvic inflammatory disease (PID) or history of PID without a subsequent intrauterine pregnancy
- Postpartum endometritis or infected abortion within the past 3 months
- Known or suspected uterine or cervical malignancy
- Known or suspected breast cancer or other progestin-sensitive cancer, current or past
- Uterine bleeding of unknown etiology
- Untreated acute cervicitis or vaginitis, including bacterial vaginosis, until infection is controlled
- Acute liver disease or liver tumor (benign or malignant)
- Conditions associated with increased susceptibility to pelvic infections
- Previously inserted IUD that has not been removed
- Hypersensitivity to any component of Mirena
- Smoking if over age 35
- Deep vein thrombosis or pulmonary embolism, current or past
- Cerebrovascular disease
- Coronary artery disease
- Thrombogenic valvular or thrombogenic rhythm diseases of the heart (e.g., subacute bacterial endocarditis with valvular disease, or atrial fibrillation)
- Inherited or acquired hypercoagulopathies
- Uncontrolled hypertension
- Diabetes mellitus with vascular disease
- Headaches with focal neurological symptoms, or migraine headaches with or without aura if over age 35
- Undiagnosed abnormal uterine bleeding
- Current or history of breast cancer which may be hormone sensitive
- Liver tumors (benign or malignant) or liver disease
Adverse Reactions
Most common (>=10%) Alterations of menstrual bleeding patterns (unscheduled uterine bleeding, decreased uterine bleeding, increased scheduled uterine bleeding), abdominal/pelvic pain, amenorrhea, headache/migraine, genital discharge, vulvovaginitis
Serious Ectopic pregnancy, intrauterine pregnancy, Group A Streptococcal sepsis, pelvic inflammatory disease, uterine perforation, expulsion, ovarian cysts
Postmarketing Arterial thrombotic and venous thromboembolic events (pulmonary embolism, deep vein thrombosis, stroke), device breakage, hypersensitivity (rash, urticaria, angioedema), increased blood pressure
Most common (>=2%) Headache (including migraines), breast pain or tenderness, menstrual disorders, nausea or vomiting, acne, mood changes, increased weight
Serious Myocardial infarction, ruptured ovarian cyst, deep vein thrombosis, focal nodular hyperplasia of the liver, uterine leiomyoma, acute cholecystitis, chronic acalculous cholecystitis
Postmarketing Venous and arterial thromboembolic events, hypertension, gallbladder disease, hepatitis, hypersensitivity, fluid retention, hypertriglyceridemia, dizziness, chloasma, angioedema, erythema nodosum, erythema multiforme, gastrointestinal symptoms, vulvovaginal candidiasis
Pharmacology
Levonorgestrel-releasing intrauterine system; works locally by thickening cervical mucus to prevent sperm passage, inhibiting sperm capacitation or survival, and altering the endometrium; ovulation is inhibited in some but not all users.
Combined oral contraceptive (COC) that lowers the risk of pregnancy primarily by suppressing ovulation; contains estradiol valerate, a synthetic prodrug of 17beta-estradiol, and dienogest, a progestin with properties of both 19-nortestosterone and progesterone derivatives.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Mirena
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (0/12) · Qty limit (0/12)
Natazia
- Covered on 5 commercial plans
- PA (2/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Mirena
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Natazia
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Mirena
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Natazia
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
$20/fillfill
Mirena Co-pay Savings ProgramCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
No savings programs available for Natazia.
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MirenaView full Mirena profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.