| Metastatic castration-resistant prostate cancer
Zytiga vs Jevtana
Side-by-side clinical, coverage, and cost comparison for metastatic castration-resistant prostate cancer.Deep comparison between: Zytiga vs Jevtana with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsJevtana has a higher rate of injection site reactions vs Zytiga based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Jevtana but not Zytiga, including UnitedHealthcare
Sign up to reveal the full AI analysis
Category
Zytiga
Jevtana
At A Glance
Oral
Daily
CYP17 inhibitor
IV infusion
Every 3 weeks
Microtubule inhibitor
Indications
- Metastatic castration-resistant prostate cancer
- Metastatic Castration-Sensitive Prostate Carcinoma
- Metastatic castration-resistant prostate cancer
Dosing
Metastatic castration-resistant prostate cancer 1,000 mg orally once daily with prednisone 5 mg orally twice daily; take on an empty stomach (no food 2 hours before or 1 hour after).
Metastatic Castration-Sensitive Prostate Carcinoma 1,000 mg orally once daily with prednisone 5 mg orally once daily; take on an empty stomach (no food 2 hours before or 1 hour after).
Metastatic castration-resistant prostate cancer 20 mg/m2 as a one-hour IV infusion every three weeks in combination with oral prednisone 10 mg daily; 25 mg/m2 may be used in select patients at the discretion of the treating healthcare provider.
Contraindications
—
- Neutrophil count <=1,500/mm3
- History of severe hypersensitivity reaction to cabazitaxel or to other drugs formulated with polysorbate 80
- Severe hepatic impairment (total bilirubin >3 x ULN)
Adverse Reactions
Most common (>=10%) Fatigue, arthralgia, hypertension, nausea, edema, hypokalemia, hot flush, diarrhea, vomiting, upper respiratory infection, cough, headache
Serious Cardiac failure, hepatotoxicity, hypokalemia (Grade 3-4), arrhythmia, cardiorespiratory arrest
Postmarketing Non-infectious pneumonitis, myopathy including rhabdomyolysis, fulminant hepatitis including acute hepatic failure and death, QT prolongation and Torsades de Pointes, anaphylactic reactions
Most common (>=10%) Anemia, leukopenia, neutropenia, thrombocytopenia, diarrhea, fatigue, nausea, vomiting, constipation, asthenia, abdominal pain, hematuria, back pain, anorexia, peripheral neuropathy, pyrexia, dyspnea, dysgeusia, cough, arthralgia, alopecia
Serious Neutropenia, leukopenia, anemia, febrile neutropenia, diarrhea, fatigue, asthenia
Postmarketing Gastritis, intestinal obstruction, interstitial pneumonia/pneumonitis, interstitial lung disease, acute respiratory distress syndrome, radiation recall hemorrhagic cystitis
Pharmacology
Abiraterone acetate is converted in vivo to abiraterone, a selective inhibitor of CYP17 (17alpha-hydroxylase/C17,20-lyase) that blocks androgen biosynthesis in testicular, adrenal, and prostatic tumor tissues, thereby reducing serum testosterone and other androgens in patients with prostate cancer.
Cabazitaxel is a microtubule inhibitor that binds to tubulin and promotes its assembly into microtubules while inhibiting disassembly, leading to stabilization of microtubules and inhibition of mitotic and interphase cellular functions.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Zytiga
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (4/12) · Qty limit (9/12)
Jevtana
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Zytiga
- Covered on 4 commercial plans
- PA (1/8) · Step Therapy (1/8) · Qty limit (0/8)
Jevtana
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Zytiga
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (2/3)
Jevtana
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
$10/momo
Janssen CarePath Savings Program: ZytigaCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAssistance Fund: Prostate Cancer
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Compare Other Drugs
Let us handle your prior authsJust enter your patient's info and we'll:
- Verify eligibility with the payer.
- Pull the right PA forms directly from the payer.
- Submit, track & send live updates to your dashboard.
Free to start · HIPAA compliant
Next Steps for Your Patient
ZytigaView full Zytiga profile
JevtanaView full Jevtana profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.