| Myasthenia Gravis, Generalized
Ultomiris vs Vyvgart
Side-by-side clinical, coverage, and cost comparison for myasthenia gravis, generalized.Deep comparison between: Ultomiris vs Vyvgart with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsVyvgart has a higher rate of injection site reactions vs Ultomiris based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Vyvgart but not Ultomiris, including UnitedHealthcare
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Category
Ultomiris
Vyvgart
At A Glance
IV infusion
Every 4-8 weeks
C5 complement inhibitor
IV infusion
Once weekly for 4 weeks per cycle
FcRn antagonist
Indications
- Paroxysmal nocturnal hemoglobinuria
- Atypical Hemolytic Uremic Syndrome
- Myasthenia Gravis, Generalized
- Neuromyelitis Optica
- Myasthenia Gravis, Generalized
Dosing
Paroxysmal nocturnal hemoglobinuria, Atypical Hemolytic Uremic Syndrome (5 to <40 kg) Weight-based IV loading dose (600-1,200 mg), followed by weight-based maintenance dose every 4 weeks (5 to <20 kg) or every 8 weeks (20 to <40 kg), starting 2 weeks after loading dose.
Paroxysmal nocturnal hemoglobinuria, Atypical Hemolytic Uremic Syndrome, Myasthenia Gravis, Generalized, Neuromyelitis Optica (>=40 kg) Weight-based IV loading dose (2,400-3,000 mg), followed by weight-based maintenance dose (3,000-3,600 mg) every 8 weeks, starting 2 weeks after loading dose.
Myasthenia Gravis, Generalized 10 mg/kg (1200 mg if >=120 kg) as IV infusion over 1 hour once weekly for 4 weeks; subsequent cycles based on clinical evaluation.
Contraindications
- Unresolved serious Neisseria meningitidis infection
- Serious hypersensitivity to efgartigimod alfa products or any excipient of VYVGART
Adverse Reactions
Most common (>=10%) Upper respiratory tract infection, headache, diarrhea, nausea, vomiting, hypertension, pyrexia, back pain, arthralgia, COVID-19
Serious Meningococcal infections, other infections (including fatal COVID-19 pneumonia and sepsis), infusion-related reactions
Postmarketing Anaphylaxis, cholestatic or mixed pattern liver injury with increased serum liver enzymes and bilirubin
Most common (>=5%) Respiratory tract infection, headache, urinary tract infection, paraesthesia, myalgia
Postmarketing Hypersensitivity reactions including anaphylaxis and hypotension, infusion-related reactions
Pharmacology
Ravulizumab-cwvz is a terminal complement inhibitor that specifically binds complement protein C5 with high affinity, preventing its cleavage to C5a (proinflammatory anaphylatoxin) and C5b (initiating subunit of the membrane attack complex), thereby inhibiting MAC formation and terminal complement-mediated tissue damage in PNH, aHUS, gMG, and NMOSD.
Efgartigimod alfa-fcab is a human IgG1 antibody fragment that binds to the neonatal Fc receptor (FcRn), reducing circulating IgG levels and AChR autoantibody levels in patients with generalized myasthenia gravis.
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Most Common Insurance
Anthem BCBS
Ultomiris
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (9/12) · Qty limit (0/12)
Vyvgart
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (9/12) · Qty limit (9/12)
UnitedHealthcare
Ultomiris
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Vyvgart
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Ultomiris
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Vyvgart
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (2/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Ultomiris.
Cost estimate not availableAccessia Health: Myasthenia Gravis - Private Insurance
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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UltomirisView full Ultomiris profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.