| Myasthenia Gravis, Generalized
Vyvgart vs Ultomiris
Side-by-side clinical, coverage, and cost comparison for myasthenia gravis, generalized.Deep comparison between: Vyvgart vs Ultomiris with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsUltomiris has a higher rate of injection site reactions vs Vyvgart based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Ultomiris but not Vyvgart, including UnitedHealthcare
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Category
Vyvgart
Ultomiris
At A Glance
IV infusion
Once weekly for 4 weeks per cycle
FcRn antagonist
IV infusion
Every 4-8 weeks
C5 complement inhibitor
Indications
- Myasthenia Gravis, Generalized
- Paroxysmal nocturnal hemoglobinuria
- Atypical Hemolytic Uremic Syndrome
- Myasthenia Gravis, Generalized
- Neuromyelitis Optica
Dosing
Myasthenia Gravis, Generalized 10 mg/kg (1200 mg if >=120 kg) as IV infusion over 1 hour once weekly for 4 weeks; subsequent cycles based on clinical evaluation.
Paroxysmal nocturnal hemoglobinuria, Atypical Hemolytic Uremic Syndrome (5 to <40 kg) Weight-based IV loading dose (600-1,200 mg), followed by weight-based maintenance dose every 4 weeks (5 to <20 kg) or every 8 weeks (20 to <40 kg), starting 2 weeks after loading dose.
Paroxysmal nocturnal hemoglobinuria, Atypical Hemolytic Uremic Syndrome, Myasthenia Gravis, Generalized, Neuromyelitis Optica (>=40 kg) Weight-based IV loading dose (2,400-3,000 mg), followed by weight-based maintenance dose (3,000-3,600 mg) every 8 weeks, starting 2 weeks after loading dose.
Contraindications
- Serious hypersensitivity to efgartigimod alfa products or any excipient of VYVGART
- Unresolved serious Neisseria meningitidis infection
Adverse Reactions
Most common (>=5%) Respiratory tract infection, headache, urinary tract infection, paraesthesia, myalgia
Postmarketing Hypersensitivity reactions including anaphylaxis and hypotension, infusion-related reactions
Most common (>=10%) Upper respiratory tract infection, headache, diarrhea, nausea, vomiting, hypertension, pyrexia, back pain, arthralgia, COVID-19
Serious Meningococcal infections, other infections (including fatal COVID-19 pneumonia and sepsis), infusion-related reactions
Postmarketing Anaphylaxis, cholestatic or mixed pattern liver injury with increased serum liver enzymes and bilirubin
Pharmacology
Efgartigimod alfa-fcab is a human IgG1 antibody fragment that binds to the neonatal Fc receptor (FcRn), reducing circulating IgG levels and AChR autoantibody levels in patients with generalized myasthenia gravis.
Ravulizumab-cwvz is a terminal complement inhibitor that specifically binds complement protein C5 with high affinity, preventing its cleavage to C5a (proinflammatory anaphylatoxin) and C5b (initiating subunit of the membrane attack complex), thereby inhibiting MAC formation and terminal complement-mediated tissue damage in PNH, aHUS, gMG, and NMOSD.
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Most Common Insurance
Anthem BCBS
Vyvgart
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (9/12) · Qty limit (9/12)
Ultomiris
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (9/12) · Qty limit (0/12)
UnitedHealthcare
Vyvgart
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Ultomiris
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Vyvgart
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (2/3) · Qty limit (0/3)
Ultomiris
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAccessia Health: Myasthenia Gravis - Private Insurance
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
No savings programs available for Ultomiris.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.