| Neutropenia
Granix vs Neupogen
Side-by-side clinical, coverage, and cost comparison for neutropenia.Deep comparison between: Granix vs Neupogen with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsNeupogen has a higher rate of injection site reactions vs Granix based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Neupogen but not Granix, including UnitedHealthcare
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Category
Granix
Neupogen
At A Glance
SC injection
Daily
G-CSF (granulocyte colony-stimulating factor)
SC injection
Daily
G-CSF
Indications
- Neutropenia
- Febrile Neutropenia
- Leukemia, Myelocytic, Acute
- Neutropenia
- Severe congenital neutropenia
- Cyclic neutropenia
- Idiopathic neutropenia
- Hematopoietic subsyndrome of acute radiation syndrome
Dosing
Neutropenia 5 mcg/kg SC once daily, starting no earlier than 24 hours after myelosuppressive chemotherapy, continued until neutrophil nadir has passed and ANC recovers to normal range; do not administer within 24 hours prior to chemotherapy.
Febrile Neutropenia, Leukemia, Myelocytic, Acute 5 mcg/kg/day SC injection, short IV infusion (15-30 min), or continuous IV infusion; administer at least 24 hours after cytotoxic chemotherapy.
Neutropenia (bone marrow transplantation) 10 mcg/kg/day IV infusion no longer than 24 hours; administer at least 24 hours after cytotoxic chemotherapy and bone marrow infusion.
Autologous PBPC collection 10 mcg/kg/day SC injection; administer for at least 4 days before first leukapheresis and continue until last leukapheresis.
Severe congenital neutropenia 6 mcg/kg SC injection twice daily.
Cyclic neutropenia, Idiopathic neutropenia 5 mcg/kg SC injection daily.
Hematopoietic subsyndrome of acute radiation syndrome 10 mcg/kg/day SC injection; administer as soon as possible after suspected or confirmed exposure to radiation doses >2 Gy.
Contraindications
- History of serious allergic reactions to filgrastim products or pegfilgrastim products
- History of serious allergic reactions to human granulocyte colony-stimulating factors such as filgrastim or pegfilgrastim
Adverse Reactions
Most common (>=1%) — adult Bone pain
Most common (>5%) — pediatric Thrombocytopenia, pyrexia, pain in extremity, headache, diarrhea
Serious Splenic rupture, acute respiratory distress syndrome, serious allergic reactions, sickle cell disorders, glomerulonephritis, capillary leak syndrome, potential for tumor growth stimulation, myelodysplastic syndrome and acute myeloid leukemia, leukocytosis, aortitis, alveolar hemorrhage
Postmarketing Sweet's syndrome (acute febrile neutrophilic dermatosis), asthenia, diarrhea, fatigue
Most common (>=5%) Pyrexia, nausea, fatigue, thrombocytopenia, bone pain, back pain, rash, dizziness, cough, dyspnea, chest pain, arthralgia
Serious Splenic rupture, acute respiratory distress syndrome, serious allergic reactions, sickle cell disorders, glomerulonephritis, alveolar hemorrhage and hemoptysis, capillary leak syndrome, myelodysplastic syndrome, acute myeloid leukemia, thrombocytopenia, leukocytosis, cutaneous vasculitis, aortitis
Postmarketing Splenic rupture, splenomegaly, anaphylaxis, sickle cell disorders, glomerulonephritis, alveolar hemorrhage and hemoptysis, capillary leak syndrome, leukocytosis, cutaneous vasculitis, Sweet's syndrome, decreased bone density and osteoporosis, myelodysplastic syndrome, acute myeloid leukemia, aortitis, extramedullary hematopoiesis
Pharmacology
Tbo-filgrastim is a recombinant human G-CSF that binds to G-CSF receptors and stimulates proliferation, differentiation, and functional activation of neutrophils to increase neutrophil counts and activity.
Filgrastim is a recombinant human G-CSF that binds to specific cell surface receptors on hematopoietic cells, stimulating neutrophil progenitor proliferation and differentiation and enhancing end-cell functional activities including phagocytic ability, respiratory burst priming, and antibody-dependent killing.
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Most Common Insurance
Anthem BCBS
Granix
- Covered on 5 commercial plans
- PA (11/12) · Step Therapy (7/12) · Qty limit (0/12)
Neupogen
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (6/12) · Qty limit (0/12)
UnitedHealthcare
Granix
- Covered on 4 commercial plans
- PA (1/8) · Step Therapy (1/8) · Qty limit (0/8)
Neupogen
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (1/8) · Qty limit (0/8)
Humana
Granix
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (1/3)
Neupogen
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (1/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableCancerCare: Chemotherapy Induced Neutropenia
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAssistance Fund: Acute Myeloid Leukemia
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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GranixView full Granix profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.