| Non-Small Cell Lung Carcinoma
Krazati vs Libtayo
Side-by-side clinical, coverage, and cost comparison for non-small cell lung carcinoma.Deep comparison between: Krazati vs Libtayo with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsLibtayo has a higher rate of injection site reactions vs Krazati based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Libtayo but not Krazati, including UnitedHealthcare
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Category
Krazati
Libtayo
At A Glance
Oral
Twice daily
KRAS G12C inhibitor
IV infusion
Every 3 weeks
PD-1 inhibitor
Indications
- Non-Small Cell Lung Carcinoma
- Colorectal Neoplasms
- Squamous cell carcinoma of skin
- Basal cell carcinoma
- Non-Small Cell Lung Carcinoma
Dosing
Non-Small Cell Lung Carcinoma 600 mg orally twice daily as a single agent until disease progression or unacceptable toxicity; swallow tablets whole with or without food.
Colorectal Neoplasms 600 mg orally twice daily in combination with cetuximab until disease progression or unacceptable toxicity; swallow tablets whole with or without food.
Squamous cell carcinoma of skin (metastatic/locally advanced) 350 mg IV infusion over 30 minutes every 3 weeks until disease progression, unacceptable toxicity, or up to 24 months.
Squamous cell carcinoma of skin (adjuvant) 350 mg IV infusion every 3 weeks for 12 weeks followed by 700 mg every 6 weeks, or 350 mg every 3 weeks, until disease recurrence, unacceptable toxicity, or up to 48 weeks.
Basal cell carcinoma 350 mg IV infusion over 30 minutes every 3 weeks until disease progression, unacceptable toxicity, or up to 24 months.
Non-Small Cell Lung Carcinoma 350 mg IV infusion every 3 weeks as single agent or in combination with platinum-based chemotherapy until disease progression or unacceptable toxicity.
Contraindications
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Adverse Reactions
Most common (>=25%) nausea, diarrhea, vomiting, fatigue, musculoskeletal pain, hepatotoxicity, renal impairment, edema, dyspnea, decreased appetite
Serious pneumonia, dyspnea, renal impairment, sepsis, respiratory failure, pleural effusion, anemia, cardiac failure
Most common (>=15%) Fatigue, musculoskeletal pain, rash, diarrhea, anemia.
Serious Immune-mediated adverse reactions (pneumonitis, colitis, hepatitis, endocrinopathies, nephritis, exfoliative dermatologic conditions, myocarditis, neurological toxicities), infusion-related reactions, allogeneic HSCT complications, pneumonia.
Pharmacology
Adagrasib is an irreversible KRAS G12C inhibitor that covalently binds to the mutant cysteine residue, locking KRAS G12C in its inactive GDP-bound state and preventing downstream signaling without affecting wild-type KRAS.
Cemiplimab-rwlc is a recombinant human IgG4 monoclonal antibody (PD-1 inhibitor) that binds to PD-1 and blocks its interaction with PD-L1 and PD-L2, releasing PD-1 pathway-mediated inhibition of the immune response, including the anti-tumor immune response.
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Most Common Insurance
Anthem BCBS
Krazati
- Covered on 5 commercial plans
- PA (11/12) · Step Therapy (0/12) · Qty limit (11/12)
Libtayo
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Krazati
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (2/8)
Libtayo
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Krazati
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Libtayo
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Krazati.
Cost estimate not availableAssistance Fund: Non-Small Cell Lung Cancer (NSCLC)
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.