| Urinary tract infection
Avycaz vs Zerbaxa
Side-by-side clinical, coverage, and cost comparison for urinary tract infection.Deep comparison between: Avycaz vs Zerbaxa with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsZerbaxa has a higher rate of injection site reactions vs Avycaz based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Zerbaxa but not Avycaz, including UnitedHealthcare
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Category
Avycaz
Zerbaxa
At A Glance
IV infusion
Every 8 hours
Cephalosporin/beta-lactamase inhibitor
IV infusion
Every 8 hours
Cephalosporin/beta-lactamase inhibitor
Indications
- Urinary Tract Infection
- Pneumonia, Bacterial
- Peritonitis
- Urinary tract infection
- Pyelonephritis
- Hospital acquired pneumonia
- VABP
Dosing
Complicated Intra-abdominal Infections, Urinary Tract Infection, Pneumonia, Bacterial 2.5 grams (ceftazidime 2 grams and avibactam 0.5 grams) IV every 8 hours infused over 2 hours in adults with CrCl > 50 mL/min; cIAI requires concurrent metronidazole; dosage adjustment required for CrCl <=50 mL/min; duration 5-14 days (cIAI) or 7-14 days (cUTI, HABP/VABP).
Peritonitis 1.5 g IV every 8 hours over 1 hour for 4 to 14 days, used in conjunction with metronidazole 500 mg IV every 8 hours; pediatric patients: 30 mg/kg up to 1.5 g every 8 hours for 5 to 14 days.
Urinary tract infection, Pyelonephritis 1.5 g IV every 8 hours over 1 hour for 7 days; pediatric patients: 30 mg/kg up to 1.5 g every 8 hours for 7 to 14 days.
Hospital acquired pneumonia, VABP 3 g IV every 8 hours over 1 hour for 8 to 14 days in adult patients 18 years and older.
Contraindications
- Known serious hypersensitivity to ceftazidime, avibactam, avibactam-containing products, or other members of the cephalosporin class
- Known serious hypersensitivity to components of ZERBAXA (ceftolozane and tazobactam), piperacillin/tazobactam, or other members of the beta-lactam class
Adverse Reactions
Most common (>=5%) Diarrhea, nausea, vomiting (cIAI); diarrhea, vomiting (HABP/VABP); nausea, diarrhea (cUTI)
Serious Hypersensitivity reactions, Clostridioides difficile-associated diarrhea, central nervous system reactions (including seizures, encephalopathy), increased mortality in patients with moderate renal impairment (CrCl 30-50 mL/min) if underdosed
Postmarketing Colitis, toxic nephropathy, hepatic dysfunction including cholestasis, hemorrhage, pancytopenia, aplastic anemia, prolonged prothrombin time, false-positive urinary glucose, acute myocardial ischemia
Most common (>=5%) Nausea, diarrhea, headache, pyrexia
Serious Hypersensitivity reactions, Clostridioides difficile-associated diarrhea, intracranial hemorrhage, renal impairment/renal failure, hepatic transaminase increased
Pharmacology
Ceftazidime is a cephalosporin that exerts bactericidal activity by binding penicillin-binding proteins of susceptible gram-negative bacteria; avibactam is a non-beta-lactam beta-lactamase inhibitor that inactivates certain beta-lactamases (including KPCs, ESBLs, and AmpC enzymes) that would otherwise degrade ceftazidime, thereby restoring ceftazidime activity against resistant organisms.
Ceftolozane is a cephalosporin antibacterial that inhibits bacterial cell wall biosynthesis by binding to penicillin-binding proteins (PBPs); tazobactam is an irreversible beta-lactamase inhibitor that extends ceftolozane activity against beta-lactamase-producing organisms.
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Most Common Insurance
Anthem BCBS
Avycaz
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (6/12) · Qty limit (0/12)
Zerbaxa
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (6/12) · Qty limit (0/12)
UnitedHealthcare
Avycaz
- Covered on 4 commercial plans
- PA (1/8) · Step Therapy (0/8) · Qty limit (0/8)
Zerbaxa
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Avycaz
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Zerbaxa
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableHealthWell: Cystic Fibrosis Treatments
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
No savings programs available for Zerbaxa.
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AvycazView full Avycaz profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.