| Chronic pain syndrome
Hysingla ER vs OxyContin
Side-by-side clinical, coverage, and cost comparison for chronic pain syndrome.Deep comparison between: Hysingla Er vs Oxycontin with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsOxycontin has a higher rate of injection site reactions vs Hysingla Er based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Oxycontin but not Hysingla Er, including UnitedHealthcare
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Category
Hysingla Er
Oxycontin
At A Glance
Oral
Once daily
Full mu-opioid agonist
Oral
Every 12 hours
Full opioid agonist
Indications
- Chronic pain syndrome
- Chronic pain syndrome
Dosing
Chronic pain syndrome Starting dose 20 mg orally once daily for opioid-naive patients; titrate in increments of 10-20 mg every 3-5 days; doses >=80 mg reserved for opioid-tolerant patients only; initiate at half the starting dose in severe hepatic impairment or moderate to severe renal impairment and end-stage renal disease.
Chronic pain syndrome Adults not opioid tolerant: initiate 10 mg orally every 12 hours; opioid-tolerant adults: individualize dose with titration every 1-2 days; pediatric patients 11 years and older already tolerating >=20 mg/day oxycodone equivalent: convert from prior opioids per established conversion factors; geriatric patients (debilitated, not opioid tolerant) and hepatic impairment: initiate at one-third to one-half the recommended starting dose and titrate carefully.
Contraindications
- Significant respiratory depression
- Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment
- Known or suspected gastrointestinal obstruction, including paralytic ileus
- Hypersensitivity to hydrocodone or any component of HYSINGLA ER
- Significant respiratory depression
- Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment
- Known or suspected gastrointestinal obstruction, including paralytic ileus
- Hypersensitivity (e.g., anaphylaxis) to oxycodone
Adverse Reactions
Most common (>=5%) Constipation, nausea, vomiting, fatigue, upper respiratory tract infection, dizziness, headache, somnolence
Serious Addiction/abuse/misuse, life-threatening respiratory depression, interactions with CNS depressants, neonatal opioid withdrawal syndrome, opioid-induced hyperalgesia and allodynia, adrenal insufficiency, severe hypotension, gastrointestinal adverse reactions, seizures, withdrawal
Postmarketing Serotonin syndrome, adrenal insufficiency, anaphylaxis, androgen deficiency, hyperalgesia and allodynia, hypoglycemia, opioid-induced esophageal dysfunction
Most common (>5%) Constipation, nausea, somnolence, dizziness, pruritus, vomiting, headache, dry mouth, asthenia, sweating
Serious Addiction/abuse/misuse, life-threatening respiratory depression, neonatal opioid withdrawal syndrome, opioid-induced hyperalgesia and allodynia, adrenal insufficiency, severe hypotension, gastrointestinal adverse reactions, seizures, withdrawal
Postmarketing Abuse, addiction, aggression, amenorrhea, cholestasis, completed suicide, death, dental caries, hyperalgesia, hypogonadism, hyponatremia, ileus, seizures, serotonin syndrome, anaphylaxis, androgen deficiency, opioid-induced esophageal dysfunction, hypoglycemia
Pharmacology
Hydrocodone is a full opioid agonist with relative selectivity for the mu-opioid receptor; it produces analgesia via CNS opioid receptors in the brain and spinal cord, and also causes respiratory depression through direct action on brainstem respiratory centers, reduced GI motility, and peripheral vasodilation.
Oxycodone is a full opioid agonist relatively selective for the mu receptor that produces analgesia through central opioid receptor activation with no ceiling effect on analgesia; it also causes respiratory depression via direct action on brain stem respiratory centers, miosis, GI motility reduction, and peripheral vasodilation.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Hysingla Er
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (0/12) · Qty limit (9/12)
Oxycontin
- Covered on 5 commercial plans
- PA (7/12) · Step Therapy (0/12) · Qty limit (1/12)
UnitedHealthcare
Hysingla Er
- Covered on 4 commercial plans
- PA (2/8) · Step Therapy (0/8) · Qty limit (3/8)
Oxycontin
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Hysingla Er
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (2/3) · Qty limit (3/3)
Oxycontin
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Hysingla Er.
No savings programs available for Oxycontin.
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Next Steps for Your Patient
Hysingla ErView full Hysingla Er profile
OxycontinView full Oxycontin profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.